Cell-based therapeutics are an emerging modality with the potential to treat many currently
intractable diseases through uniquely powerful modes of action. Despite notable recent …

Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

Swimming microrobots guided in the circulation system offer considerable promise in
precision medicine but currently suffer from problems such as limited adhesion to blood …

Medical micro/nanorobots have received tremendous attention over the past decades owing
to their potential to be navigated into hard-to-reach tissues for a number of biomedical …

Endothelial cells (ECs) lining all blood vessels are subjected to large mechanical stresses
that regulate their structure and function in health and disease. Here, we review EC …

There is a growing awareness that complex 3-dimensional (3D) organs are not well
represented by monolayers of a single cell type–the standard format for many drug screens …

Although acute coronary syndromes (ACS) remain one of the leading causes of death, the
clinical presentation has changed over the past three decades with a decline in the …

It has been more than 100 years since Paul Ehrlich reported that various water-soluble dyes
injected into the circulation did not enter the brain. Since Ehrlich's first experiments, only a …

Cells are constantly submitted to external mechanical stresses, which they must withstand
and respond to. By forming a physical boundary between cells and their environment that is …

Von Willebrand factor, an ultralarge concatemeric blood protein, must bind to platelet GPIbα
during bleeding to mediate hemostasis, but not in the normal circulation to avoid thrombosis …