Background Membrane proteins constitute a major group of proteins and are of great
significance as pharmaceutical targets, but underrepresented in the Protein Data Bank …

Nanopore sensing has emerged as a versatile approach to detection and identification of
biomolecules. Presently, researchers rely on experience and intuition for choosing or …

The effects of detergent sodium dodecyl sulfate (SDS) on protein structure and dynamics are
fundamental to the most common laboratory technique used to separate proteins and …

Protein detection in complex biological fluids has wide-ranging significance across
proteomics and molecular medicine. Existing detectors cannot readily distinguish between …

Molecular-profiling-based cancer diagnosis has significant implications for predicting
disease prognosis and selecting targeted therapeutic interventions. The analysis of cancer …

Transcription factors often interact with other protein cofactors, regulating gene expression.
Direct detection of these brief events using existing technologies remains challenging due to …

Protein sequencing holds the key to unveiling protein dynamics, which is significant for
molecular diagnostics and drug design. Single‐molecule sensing based on 2D nanopores …

Previous studies of transmembrane protein channels have employed noise analysis to
examine their statistical current fluctuations. In general, these explorations determined a …

DNA nanopores offer a unique nano-scale foothold at the membrane interface that can help
advance the life sciences as biophysical research tools or gate-keepers for drug delivery …

To maintain membrane proteins soluble in aqueous solution, amphipathic compounds are
used to shield the hydrophobic patch of their membrane insertion, which forms a belt around …