Allogeneic transplantation of hematopoietic cells is an effective treatment of leukemia, even
in advanced stages. Allogeneic lymphocytes produce a strong graft-versus-leukemia (GVL) …

There is a strong graft-versus-leukemia (GVL) effect of allogeneic stem cell transplantation
(SCT) due to elimination of tumor cells by alloimmune effector lymphocytes. When leukemia …

The NCCN Guidelines for Acute Lymphoblastic Leukemia (ALL) focus on the classification of
ALL subtypes based on immunophenotype and cytogenetic/molecular markers; risk …

Chimeric antigen receptor–modified T cells with specificity for CD19 have shown promise in
the treatment of chronic lymphocytic leukemia (CLL). It remains to be established whether …

The prognosis of relapsed acute lymphoblastic leukemia (ALL) after allogeneic
transplantation is dismal when treated with conventional approaches. While single‐target …

To develop a therapy for drug-resistant B-lineage acute lymphoblastic leukemia (ALL), we
transduced T lymphocytes with anti-CD19 chimeric receptors, consisting of an anti-CD19 …

Natural killer (NK) cells hold promise for improving the therapeutic potential of allogeneic
hematopoietic transplantation, but their effectiveness is limited by inhibitory HLA types. We …

The adoptive transfer of donor T cells that have been genetically modified to recognize
leukemia could prevent or treat leukemia relapse after allogeneic HSCT (allo-HSCT) …

The role of hematopoietic cell transplantation (HCT) in adults with acute lymphoblastic
leukemia (ALL) is reviewed and critically evaluated in this systematic evidence-based …

Treatment of acute lymphoblastic leukemia (ALL) continues to advance, as evidenced by the
improved risk stratification of patients and development of newer treatment options …