All causes of renal allograft injury, when severe and/or sustained, can result in chronic
histological damage of which interstitial fibrosis and tubular atrophy are dominant features …

Background The introduction of solid-phase immunoassay (SPI) technology for the detection
and characterization of human leukocyte antigen (HLA) antibodies in transplantation while …

Understanding rates and determinants of clinical pathologic progression for recipients with
de novo donor-specific antibody (dnDSA), especially subclinical dnDSA, may identify …

Long-term kidney transplant outcomes remain suboptimal, delineating an unmet medical
need. Although current immunosuppressive therapy in kidney transplant recipients is …

Background Declining rates of acute rejection (AR) and the high rate of 1-year graft survival
among patients with AR have prompted re-examination of AR as an outcome in the clinic …

Kidney allografts are frequently lost due to alloimmunity. Still, the impact of early acute
rejection (AR) on long-term graft survival is debated. We examined this relationship focusing …

The pathological diagnosis of borderline rejection (BL-R) denotes possible T cell–mediated
rejection (TCMR), but its clinical significance is uncertain. This single-center, cross-sectional …

Recent cross-sectional studies suggest an important role for transitional B lymphocytes
(CD19+ CD24hiCD38hi) in promoting transplant tolerance, and protecting from late antibody …

Background In kidney transplant recipients, surveillance biopsies can reveal, despite stable
graft function, histologic features of acute rejection and borderline changes that are …

There are no minimally invasive diagnostic metrics for acute kidney transplant rejection
(AR), especially in the setting of the common confounding diagnosis, acute dysfunction with …