This review covers several aspects of microfluidic devices used for culturing and monitoring
of both adherent and non-adherent cells, including a multitude of applications. A comparison …

In aerobic bioprocesses, oxygen is a key substrate; due to its low solubility in broths
(aqueous solutions), a continuous supply is needed. The oxygen transfer rate (OTR) must be …

Competitive sustainable production in industry demands new and better biocatalysts,
optimized bioprocesses and cost-effective product recovery. Our review sheds light on the …

The interest in a fast, high specific and reliable detection method for bacteria identification is
increasing. We will show that the application of vibrational spectroscopy is feasible for the …

Biotechnology process development involves strain testing and improvement steps aimed at
increasing yields and productivity. This necessitates the high-throughput screening of many …

Bioprocess development today is slow and expensive compared to chemical process
development. A drastic paradigm shift is necessary and possible by the consistent …

This review focuses on recent progress in the technology of high throughput (HTP)
cultivation and its increasing application in quality by design (QbD)-driven bioprocess …

In industrial‐scale biotechnological processes, the active control of the pH‐value combined
with the controlled feeding of substrate solutions (fed‐batch) is the standard strategy to …

Advances in high‐throughput process development and optimization involve the rational
use of miniaturized stirred bioreactors, instrumented shaken flasks and microtiter plates. As …

The sustainable use of resources by Nature to synthesize the required products at the right
place, when they are needed, continues to be the role model for total synthesis and …