The link between obesity and puberty: what is new?

A Huang, CL Roth - Current Opinion in Pediatrics, 2021 - journals.lww.com
Understanding how the interactions of these factors contribute the relationship between
obesity and early pubertal onset is crucial as early puberty has been linked with long-term …

[HTML][HTML] Genetic and epigenetic control of puberty

MC Manotas, DM González, C Céspedes… - Sexual …, 2022 - karger.com
Puberty is a complex transitional phase in which reproductive capacity is achieved. There is
a very wide variation in the age range of the onset of puberty, which follows a familial, ethnic …

[HTML][HTML] Genetic factors in precocious puberty

YS Shim, HS Lee, JS Hwang - Clinical and Experimental Pediatrics, 2022 - ncbi.nlm.nih.gov
Pubertal onset is known to result from reactivation of the hypothalamic-pituitary-gonadal
(HPG) axis, which is controlled by complex interactions of genetic and nongenetic factors …

The Makorin lep-2 and the lncRNA lep-5 regulate lin-28 to schedule sexual maturation of the C. elegans nervous system

H Lawson, E Vuong, RM Miller, K Kiontke, DHA Fitch… - Elife, 2019 - elifesciences.org
Sexual maturation must occur on a controlled developmental schedule. In mammals,
Makorin3 (MKRN3) and the miRNA regulators LIN28A/B are key regulators of this process …

[HTML][HTML] MKRN3 and KISS1R mutations in precocious and early puberty

S Pagani, V Calcaterra, G Acquafredda… - Italian Journal of …, 2020 - Springer
Background Pubertal timing is known to be influenced by interactions among various
genetic, nutritional, environmental and socio-economic factors, although the ultimate …

Pubertal orchestration of hormones and testis in primates

I Bhattacharya, S Sen Sharma… - Molecular …, 2019 - Wiley Online Library
The term “Puberty”, socially known as “Adolescence” is the transitional period from juvenile
life to adulthood with functional maturation of gonads and genital organs. In this process …

The Effect of Secondary Sexual Characteristics Outset Time Abnormality on Addiction in Adults: a Mendelian Randomization Study

C Pan, C Li, S Cheng, Y Chen, J Zhang… - International Journal of …, 2023 - Springer
The abnormal timing of pubertal development is a risk factor for addictive disorders among
adolescents. However, whether the precocious or late puberty has influence on addiction in …

A comprehensive metaanalysis to identify susceptibility genetic variants for precocious puberty

X Gu, W Xiong, Y Yang, H Li… - Annals of Human …, 2024 - Wiley Online Library
Purpose Currently, several genetic variants in ERα gene (rs2234693 and rs9340799), ERβ
gene (rs1256049 and rs4986938), KISS1 gene (rs4889, rs1132506 and rs5780218) …

MiR-664-2 impacts pubertal development in a precocious-puberty rat model through targeting the NMDA receptor-1

M Ju, L Yang, J Zhu, Z Chen, M Zhang… - Biology of …, 2019 - academic.oup.com
Precocious puberty (PP) commonly results from premature activation of the hypothalamic–
pituitary–gonadal axis (HPGA). Gonadotropin-releasing hormone (GnRH) is the initial trigger …

[HTML][HTML] 遗传缺陷致中枢性性早熟病因学的研究新进展

张余韵, 罗飞宏 - Chinese Journal of Contemporary Pediatrics, 2024 - ncbi.nlm.nih.gov
中枢性性早熟( central precocious puberty, CPP) 是下丘脑-垂体-性腺轴提早激活所导致的
发育异常性疾病, 其发病率快速增加, 但发病机制尚未完全明确。 既往研究发现KISS1R …