Understanding how the interactions of these factors contribute the relationship between
obesity and early pubertal onset is crucial as early puberty has been linked with long-term …

Puberty is a complex transitional phase in which reproductive capacity is achieved. There is
a very wide variation in the age range of the onset of puberty, which follows a familial, ethnic …

Pubertal onset is known to result from reactivation of the hypothalamic-pituitary-gonadal
(HPG) axis, which is controlled by complex interactions of genetic and nongenetic factors …

Sexual maturation must occur on a controlled developmental schedule. In mammals,
Makorin3 (MKRN3) and the miRNA regulators LIN28A/B are key regulators of this process …

Background Pubertal timing is known to be influenced by interactions among various
genetic, nutritional, environmental and socio-economic factors, although the ultimate …

The term “Puberty”, socially known as “Adolescence” is the transitional period from juvenile
life to adulthood with functional maturation of gonads and genital organs. In this process …

The abnormal timing of pubertal development is a risk factor for addictive disorders among
adolescents. However, whether the precocious or late puberty has influence on addiction in …

Purpose Currently, several genetic variants in ERα gene (rs2234693 and rs9340799), ERβ
gene (rs1256049 and rs4986938), KISS1 gene (rs4889, rs1132506 and rs5780218) …

Precocious puberty (PP) commonly results from premature activation of the hypothalamic–
pituitary–gonadal axis (HPGA). Gonadotropin-releasing hormone (GnRH) is the initial trigger …

中枢性性早熟（ central precocious puberty, CPP） 是下丘脑-垂体-性腺轴提早激活所导致的
发育异常性疾病， 其发病率快速增加， 但发病机制尚未完全明确。 既往研究发现KISS1R …