Multivalent glycocyclopeptides: conjugation methods and biological applications

D Goyard, AMS Ortiz, D Boturyn… - Chemical Society …, 2022 - pubs.rsc.org
Click chemistry was extensively used to decorate synthetic multivalent scaffolds with glycans
to mimic the cell surface glycocalyx and to develop applications in glycosciences …

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: an update for 2015–2016

DJ Harvey - Mass Spectrometry Reviews, 2021 - Wiley Online Library
This review is the ninth update of the original article published in 1999 on the application of
matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry to the analysis of …

The study of multivalent carbohydrate–protein interactions by bio-layer interferometry

E Laigre, D Goyard, C Tiertant, J Dejeu… - Organic & biomolecular …, 2018 - pubs.rsc.org
The study of complex multivalent carbohydrate–protein interactions remains highly
complicated and sometimes rendered impossible due to aggregation problems. In this study …

Chemical synthesis and immunological evaluation of new generation multivalent anticancer vaccines based on a Tn antigen analogue

C Pifferi, A Ruiz-de-Angulo, D Goyard, C Tiertant… - Chemical …, 2020 - pubs.rsc.org
Tumor associated carbohydrate antigens (TACAs), such as the Tn antigen, have emerged
as key targets for the development of synthetic anticancer vaccines. However, the induction …

Multivalent glycomimetics with affinity and selectivity toward fucose-binding receptors from emerging pathogens

D Goyard, V Baldoneschi, A Varrot, M Fiore… - Bioconjugate …, 2018 - ACS Publications
Bacterial and fungal pathogens involved in lung infection in cystic fibrosis patients utilize a
particular family of glycan-binding proteins, characterized by the presentation of six fucose …

Heterovalent glycodendrimers as epitope carriers for antitumor synthetic vaccines

C Pifferi, B Thomas, D Goyard, N Berthet… - … A European Journal, 2017 - Wiley Online Library
The large majority of TACA‐based (TACA= Tumor‐Associated Carbohydrate Antigens)
antitumor vaccines target only one carbohydrate antigen, thereby often resulting in the …

Recent advances in the chemistry of glycoconjugate amphiphiles

L Latxague, A Gaubert, P Barthélémy - Molecules, 2018 - mdpi.com
Glyconanoparticles essentially result from the (covalent or noncovalent) association of
nanometer-scale objects with carbohydrates. Such glyconanoparticles can take many …

The advanced synthetic modifications and applications of multifunctional PAMAM dendritic composites

RY Patle, JS Meshram - Reaction Chemistry & Engineering, 2022 - pubs.rsc.org
The profound advances in dendrimer chemistry have led to new horizons in polymer
science. Moreover, this has promisingly uncovered opportunities to develop new versatile …

Heteroglycoclusters With Dual Nanomolar Affinities for the Lectins LecA and LecB From Pseudomonas aeruginosa

D Goyard, B Thomas, E Gillon, A Imberty… - Frontiers in …, 2019 - frontiersin.org
Multivalent structures displaying different instead of similar sugar units, namely
heteroglycoclusters (hGCs), are stimulating the efforts of glycochemists for developing …

Synthesis of Mannosylated Glycodendrimers and Evaluation against BC2L‐A Lectin from Burkholderia Cenocepacia

C Pifferi, D Goyard, E Gillon, A Imberty… - …, 2017 - Wiley Online Library
Chronic colonization of lungs by opportunist bacteria is the major cause of mortality for cystic
fibrosis patients. Among these pathogens, Burkholderia cenocepacia is responsible for …