Transforming growth factor beta (TGF-β) is the most potent pro-fibrogenic cytokine and its
expression is increased in almost all of fibrotic diseases. Although signaling through Smad …

Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterized by an
abnormal reepithelialisation, an excessive tissue remodelling and a progressive fibrosis …

Antioxidant enzymes form the first line of defense against free radicals in organisms. Their
regulation depends mainly on the oxidant status of the cell, given that oxidants are their …

Different animal models of pulmonary fibrosis have been developed to investigate potential
therapies for idiopathic pulmonary fibrosis (IPF). The most common is the bleomycin model …

Transforming growth factor β (TGF-β) is the most potent and ubiquitous profibrogenic
cytokine, and its expression is increased in almost all the fibrotic diseases and in …

Abstract Melatonin (N‐acetyl‐5‐methoxytryptamine) is a molecule with a very wide
phylogenetic distribution from plants to man. In vertebrates, melatonin was initially thought to …

Melatonin has the ability to intervene in the initiation, progression and metastasis of some
experimental cancers. A large variety of potential mechanisms have been advanced to …

Fibrosis is a common occurrence following organ injury and failure. To date, there is no
effective treatment for this condition. Melatonin targets numerous molecular pathways, a …

Fibrosis is characterized by excessive accumulation of extracellular matrix (ECM) in
basement membranes and interstitial tissues, resulting from increased synthesis or …

Melatonin is reported to exhibit a wide variety of biological effects, including antioxidant and
anti-inflammatory. Evidence shows the important role of oxidative stress in the …