Microbiome-based therapeutics

MT Sorbara, EG Pamer - Nature Reviews Microbiology, 2022 - nature.com
Symbiotic microorganisms inhabiting the gastrointestinal tract promote health by decreasing
susceptibility to infection and enhancing resistance to a range of diseases. In this Review …

[HTML][HTML] Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations

H Zhu, D Bi, Y Zhang, C Kong, J Du, X Wu… - Signal transduction and …, 2022 - nature.com
The ketogenic diet (KD) is a high-fat, adequate-protein, and very-low-carbohydrate diet
regimen that mimics the metabolism of the fasting state to induce the production of ketone …

Gut microbiota in human metabolic health and disease

Y Fan, O Pedersen - Nature Reviews Microbiology, 2021 - nature.com
Observational findings achieved during the past two decades suggest that the intestinal
microbiota may contribute to the metabolic health of the human host and, when aberrant, to …

[PDF][PDF] Rethinking healthy eating in light of the gut microbiome

AM Armet, EC Deehan, AF O'Sullivan, JF Mota… - Cell Host & Microbe, 2022 - cell.com
Given the worldwide epidemic of diet-related chronic diseases, evidence-based dietary
recommendations are fundamentally important for health promotion. Despite the importance …

[PDF][PDF] Developmental trajectory of the healthy human gut microbiota during the first 5 years of life

J Roswall, LM Olsson, P Kovatcheva-Datchary… - Cell host & …, 2021 - cell.com
The gut is inhabited by a densely populated ecosystem, the gut microbiota, that is
established at birth. However, the succession by which different bacteria are incorporated …

[PDF][PDF] Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection

ES Winkler, P Gilchuk, J Yu, AL Bailey, RE Chen… - Cell, 2021 - cell.com
SARS-CoV-2 has caused the global COVID-19 pandemic. Although passively delivered
neutralizing antibodies against SARS-CoV-2 show promise in clinical trials, their mechanism …

The maternal microbiome modulates fetal neurodevelopment in mice

HE Vuong, GN Pronovost, DW Williams, EJL Coley… - Nature, 2020 - nature.com
Abstract 'Dysbiosis' of the maternal gut microbiome, in response to challenges such as
infection, altered diet and stress during pregnancy, has been increasingly associated with …

The healthy microbiome—what is the definition of a healthy gut microbiome?

F Shanahan, TS Ghosh, PW O'Toole - Gastroenterology, 2021 - Elsevier
Use of microbiome-based biomarkers in diagnosis, prognosis, risk profiling, and precision
therapy requires definition of a healthy microbiome in different populations. To determine …

[HTML][HTML] Diet and the microbiota–gut–brain axis: sowing the seeds of good mental health

K Berding, K Vlckova, W Marx, H Schellekens… - Advances in …, 2021 - Elsevier
Over the past decade, the gut microbiota has emerged as a key component in regulating
brain processes and behavior. Diet is one of the major factors involved in shaping the gut …

Developmental origins of metabolic diseases

DJ Hoffman, TL Powell, ES Barrett… - Physiological …, 2021 - journals.physiology.org
Almost 2 billion adults in the world are overweight, and more than half of them are classified
as obese, while nearly one-third of children globally experience poor growth and …