Subgenomic flavivirus RNA as key target for live-attenuated vaccine development

K Doets, GP Pijlman - Journal of Virology, 2024 - Am Soc Microbiol
Live-attenuated flavivirus vaccines confer long-term protection against disease, but the
design of attenuated flaviviruses does not follow a general approach. The non-coding …

Zika virus dumbbell-1 structure is critical for sfRNA presence and cytopathic effect during infection

ME Graham, C Merrick, BM Akiyama, MJ Szucs… - Mbio, 2023 - Am Soc Microbiol
All flaviviruses contain conserved RNA structures in the 3′ untranslated region (3′ UTR)
that are important for flavivirus RNA replication, translation, and pathogenesis. Flaviviruses …

Pan-flavivirus analysis reveals sfRNA-independent, 3′ UTR-biased siRNA production from an insect-specific flavivirus

B Besson, GJ Overheul, MT Wolfinger… - Journal of …, 2024 - journals.asm.org
ABSTRACT RNA interference (RNAi) plays an essential role in mosquito antiviral immunity,
but it is not known whether viral small interfering RNA (siRNA) profiles differ between …

Exosome-mediated viral nucleic acid presentation in a crustacean expounds innate immunity from a novel perspective

Y Gong, H Hu, X Zhao, W Wei, M Zhang… - Journal of …, 2024 - journals.asm.org
As an enduring hot topic in the field of innate immunity, apoptosis is widely considered an
effective approach to eliminate pathogenic microbes and plays a crucial role during host …

A New Subclass of Exoribonuclease-Resistant RNA Found in Multiple Genera of Flaviviridae

MJ Szucs, PJ Nichols, RA Jones, Q Vicens, JS Kieft - MBio, 2020 - Am Soc Microbiol
Viruses have developed innovative strategies to exploit the cellular machinery and
overcome the antiviral defenses of the host, often using specifically structured RNA …