Successful pregnancy requires carefully-coordinated communications between the mother
and fetus. Immune cells and cytokine signaling pathways participate as mediators of these …

Some maternal infections, contracted before or during pregnancy, can be transmitted to the
fetus, during gestation (congenital infection), during labor and childbirth (perinatal infection) …

Studying tissue composition and function in non-human primates (NHPs) is crucial to
understand the nature of our own species. Here we present a large-scale cell transcriptomic …

Multiple non-animal-based test methods have never been formally validated. In order to use
such new approach methods (NAMs) in a regulatory context, criteria to define their …

Although the currently available pharmacological assays can cure most pathological
disorders, they have limited therapeutic value in relieving certain disorders like myocardial …

Creating a functional cerebral cortex requires a series of complex and well-coordinated
developmental steps. These steps have evolved across species with the emergence of …

In this project we set up a human cell‐based DNTin vitro testing strategy that is based on test
methods with high readiness and data generated therefrom. The methods underwent afit‐for …

Microcephaly or reduced head circumference results from a multitude of abnormal
developmental processes affecting brain growth and/or leading to brain atrophy. Autosomal …

The aim of this study was the investigation of the in vitro antioxidant, antidiabetic,
dermatoprotective, antidermatophyte, and antibacterial properties of Mentha viridis essential …

Recombinant adeno-associated virus (rAAV) has been widely used as a viral vector across
mammalian biology and has been shown to be safe and effective in human gene therapy …