Mesenchymal stem cell-derived secretome: a potential therapeutic option for autoimmune and immune-mediated inflammatory diseases

G Műzes, F Sipos - Cells, 2022 - mdpi.com
Immune-mediated inflammatory diseases (IMIDs) encompass several entities such as
“classic” autoimmune disorders or immune-mediated diseases with autoinflammatory …

Extracellular vesicle-mediated interorgan communication in metabolic diseases

S Hu, Y Hu, W Yan - Trends in Endocrinology & Metabolism, 2023 - cell.com
The body partially maintains metabolic homeostasis through interorgan communication
between metabolic organs under physiological conditions. This crosstalk is known to be …

Emerging mechanisms of obesity-associated immune dysfunction

SR Shaikh, MA Beck, Y Alwarawrah… - Nature Reviews …, 2024 - nature.com
Obesity is associated with a wide range of complications, including type 2 diabetes mellitus,
cardiovascular disease, hypertension and nonalcoholic fatty liver disease. Obesity also …

Toll-like receptors (TLRs) in health and disease: an overview

V Kumar, JE Barrett - Toll-like Receptors in Health and Disease, 2022 - Springer
Toll-like receptors were discovered as proteins playing a crucial role in the dorsoventral
patterning during embryonic development in the Drosophila melanogaster (D …

Role of dendritic cell‑derived exosomes in allergic rhinitis

C Kang, H He, P Liu, Y Liu, X Li… - International …, 2023 - spandidos-publications.com
Allergic rhinitis (AR) is a common pathological condition in otorhinolaryngology. Its
prevalence has been increasing worldwide and is becoming a major burden to the world …

Understanding exosomes: Part 2—Emerging leaders in regenerative medicine

RJ Miron, NE Estrin, A Sculean… - Periodontology 2000, 2024 - Wiley Online Library
Exosomes are the smallest subset of extracellular signaling vesicles secreted by most cells
with the ability to communicate with other tissues and cell types over long distances. Their …

Research progress on the mechanism of interleukin-1β on epiphyseal plate chondrocytes

Z Tong, X Yang, J Li - European Journal of Medical Research, 2022 - Springer
Epiphyseal plate injury, a common problem in pediatric orthopedics, may result in poor bone
repair or growth defects. Epiphyseal plate, also known as growth plate is a layer of hyaline …

Chasing Uterine Cancer with NK Cell-Based Immunotherapies

V Kumar, C Bauer, JH Stewart IV - Future Pharmacology, 2022 - mdpi.com
Gynecological cancers, including endometrial adenocarcinoma, significantly contribute to
cancer incidence and mortality worldwide. The immune system plays a significant role in …

Circulating extracellular vesicles impair mesenchymal stromal cell differentiation favoring adipogenic rather than osteogenic differentiation in adolescents with obesity

B Peruzzi, E Urciuoli, M Mariani, L Chioma… - International Journal of …, 2022 - mdpi.com
Excess body weight has been considered beneficial to bone health because of its anabolic
effect on bone formation; however, this results in a poor quality bone structure. In this …

Modulation of adipose tissue metabolism by exosomes in obesity

Y Xu, L Huang, Y Zhuang… - American Journal of …, 2024 - journals.physiology.org
Obesity and its related metabolic complications represent a significant global health
challenge. Central to this is the dysregulation of glucolipid metabolism, with a predominant …