Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …

The concept of early termination as an important means of transcriptional control has long
been established. Even so, its role in metazoan gene expression is underappreciated …

The key RNA sequence elements and protein factors necessary for 3′ processing of
polyadenylated mRNA precursors are well known. Recent studies, however, have …

Polyadenylation of mRNA precursors is mediated by a large multisubunit protein complex.
Here we show that RBBP6 (retinoblastoma-binding protein 6), identified initially as an Rb …

Alternative polyadenylation (APA) is a molecular mechanism during a pre‐mRNA
processing that involves usage of more than one polyadenylation site (PA‐site) generating …

Simple Summary We summarized and cataloged the E3 ligases involved in endometrial
carcinoma (EC) and cervical cancer (CC). Finally, an overview of the current drugs that …

Faithful DNA replication is essential for the maintenance of genome integrity. Incomplete
genome replication leads to DNA breaks and chromosomal rearrangements, which are …

The risk of developing a solid cancer is a major issue arising in the disease course of a
myeloproliferative neoplasm (MPN). Although the connection between the two diseases has …

Retinoblastoma binding protein 6 (RBBP6) plays an important role in chaperone-mediated
ubiquitination and interacts with TP53 in carcinogenesis. However, the clinicopathologic …

The cleavage and polyadenylation specificity factor (CPSF) complex plays a central role in
the formation of mRNA 3′ ends, being responsible for the recognition of the poly (A) signal …