Alopecia areata (AA) is a common, inflammatory, nonscarring type of hair loss. Significant
variations in the clinical presentation of AA have been observed, ranging from small, well …

The proper restraint of the destructive potential of the immune system is essential for
maintaining health. Regulatory T (Treg) cells ensure immune homeostasis through their …

While many genetic variants have been associated with risk for human diseases, how these
variants affect gene expression in various cell types remains largely unknown. To address …

Malignant tumors can evade destruction by the immune system by attracting immune-
suppressive regulatory T cells (Treg) cells. The IKZF2 (Helios) transcription factor plays a …

T regulatory cells suppress a variety of immune responses to self-antigens and play a role in
peripheral tolerance maintenance by limiting autoimmune disorders, and other pathological …

Naturally arising regulatory CD4+ T (Treg) cells, which specifically express the transcription
factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a T-cell …

Vitiligo is a complex disease whose pathogenesis results from the interaction of genetic
components, metabolic factors linked to cellular oxidative stress, melanocyte adhesion to the …

Background Alopecia areata is a disorder that results in nonscarring hair loss. The
psychological impact can be significant, leading to feelings of depression and social …

T cell activation requires that the cell meet increased energetic and biosynthetic demands.
We showed that exogenous nutrient availability regulated the differentiation of naïve CD4+ T …

Immune dysregulation, polyendocrinopathy, enteropathy, X‐linked (IPEX) syndrome is a
rare disorder that increasingly has gained attention as a model of genetic autoimmunity …