Novel N-Acyl Hydrazone Compounds as Promising Anticancer Agents: Synthesis and Molecular Docking Studies

Y Biliz, B Hasdemir, H Başpınar Küçük… - ACS …, 2023 - ACS Publications
In this study, a new series of N-acyl hydrazones 7a-e, 8a-e, and 9a-e, starting from methyl δ-
oxo pentanoate with different substituted groups 1a-e, were synthesized as anticancer …

Synthesis of new pyrazolidines by [3+ 2] cycloaddition: Anticancer, antioxidant activities, and molecular docking studies

Y Biliz, B Hasdemir, HB Küçük, S Yıldırım… - Journal of Molecular …, 2024 - Elsevier
A series of novel pyrazolidine derivatives 2a-j from N-acyl hydrazones 1a-j were designed
and synthesized by N-triflylphosphoramide (NTPA) catalyzed [3+ 2] cycloaddition. The …

Asymmetric Synthesis of Chiral γ‐and δ‐Amino Esters Using Trichlorosilane Activated with a Lewis Base Catalyst

B Hasdemir, H Yaşa, T Yıldız, HB Küçük… - …, 2020 - Wiley Online Library
Novel chiral γ‐and δ‐amino esters 2 a–k were synthesized by enantioselective reduction of
N‐aryl γ‐and δ‐imino esters with aryl, substituted aryl, and heteroaryl groups 1 a–k using …

Synthesis, characterization, antioxidant evaluation, molecular docking and density functional theory studies of phenyl and naphthyl based esters

M Shabbir, Z Akhter, MA Asghar, V Mckee… - Journal of Molecular …, 2020 - Elsevier
Two phenol based esters phenyl benzoate (OE 1) and 1-naphthyl benzoate (OE 2) were
synthesized from phenol/1-naphthol and benzoyl chloride respectively. The structural …

Synthesis of novel 1, 2, 3-thiadizoles and 1, 2, 3-selenadiazoles as new antimicrobial agents

HB Küçük, ZB Salt, EM Kara, AS Mehan… - … , Sulfur, and Silicon …, 2019 - Taylor & Francis
Abstract A series of novel 1, 2, 3-thiadiazoles and 1, 2, 3-selenadiazoles having a long alkyl
chain were synthesized by reacting semicarbazones with SOCl 2 and SeO 2, respectively …