The role of microglia and macrophages in glioma maintenance and progression
D Hambardzumyan, DH Gutmann… - Nature neuroscience, 2016 - nature.com
There is a growing recognition that gliomas are complex tumors composed of neoplastic and
non-neoplastic cells, which each individually contribute to cancer formation, progression …
non-neoplastic cells, which each individually contribute to cancer formation, progression …
[HTML][HTML] CAR-engineered NK cells for the treatment of glioblastoma: turning innate effectors into precision tools for cancer immunotherapy
Glioblastoma (GB) is the most common and aggressive primary brain tumor in adults and
currently incurable. Despite multimodal treatment regimens, median survival in unselected …
currently incurable. Despite multimodal treatment regimens, median survival in unselected …
Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth
Tumour-associated macrophages (TAMs) are enriched in glioblastoma multiformes (GBMs)
that contain glioma stem cells (GSCs) at the apex of their cellular hierarchy. The correlation …
that contain glioma stem cells (GSCs) at the apex of their cellular hierarchy. The correlation …
Programmed death ligand 1 expression and tumor-infiltrating lymphocytes in glioblastoma
AS Berghoff, B Kiesel, G Widhalm, O Rajky… - Neuro …, 2015 - academic.oup.com
Background Immune checkpoint inhibitors targeting programmed cell death 1 (PD1) or its
ligand (PD-L1) showed activity in several cancer types. Methods We performed …
ligand (PD-L1) showed activity in several cancer types. Methods We performed …
Immune biology of glioma-associated macrophages and microglia: functional and therapeutic implications
CNS immune defenses are marshaled and dominated by brain resident macrophages and
microglia, which are the innate immune sentinels and frontline host immune barriers against …
microglia, which are the innate immune sentinels and frontline host immune barriers against …
Tumor infiltrating immune cells in gliomas and meningiomas
P Domingues, M González-Tablas, Á Otero… - Brain, behavior, and …, 2016 - Elsevier
Tumor-infiltrating immune cells are part of a complex microenvironment that promotes and/or
regulates tumor development and growth. Depending on the type of cells and their …
regulates tumor development and growth. Depending on the type of cells and their …
[HTML][HTML] Current perspectives on diffuse midline glioma and a different role for the immune microenvironment compared to glioblastoma
CJ Pachocki, EM Hol - Journal of neuroinflammation, 2022 - Springer
Diffuse midline glioma (DMG), formerly called diffuse intrinsic pontine glioma (DIPG), is a
high-grade malignant pediatric brain tumor with a near-zero survival rate. To date, only …
high-grade malignant pediatric brain tumor with a near-zero survival rate. To date, only …
Characterization of distinct immunophenotypes across pediatric brain tumor types
AM Griesinger, DK Birks, AM Donson… - The Journal of …, 2013 - journals.aai.org
Despite increasing evidence that antitumor immune control exists in the pediatric brain,
these findings have yet to be exploited successfully in the clinic. A barrier to development of …
these findings have yet to be exploited successfully in the clinic. A barrier to development of …
[HTML][HTML] Advances in NK cell therapy for brain tumors
J Fares, ZB Davis, JS Rechberger, SA Toll… - NPJ Precision …, 2023 - nature.com
Despite advances in treatment regimens that comprise surgery, chemotherapy, and
radiation, outcome of many brain tumors remains dismal, more so when they recur. The …
radiation, outcome of many brain tumors remains dismal, more so when they recur. The …
[HTML][HTML] The interplay between glioblastoma and its microenvironment
GBM is the most common primary brain tumor in adults, and the aggressive nature of this
tumor contributes to its extremely poor prognosis. Over the years, the heterogeneous and …
tumor contributes to its extremely poor prognosis. Over the years, the heterogeneous and …