Safety of the fungal workhorses of industrial biotechnology: update on the mycotoxin and secondary metabolite potential of Aspergillus niger, Aspergillus oryzae, and …

JC Frisvad, LLH Møller, TO Larsen, R Kumar… - Applied Microbiology …, 2018 - Springer
This review presents an update on the current knowledge of the secondary metabolite
potential of the major fungal species used in industrial biotechnology, ie, Aspergillus niger …

Taxonomy of Aspergillus section Flavi and their production of aflatoxins, ochratoxins and other mycotoxins

JC Frisvad, V Hubka, CN Ezekiel, SB Hong… - Studies in …, 2019 - ingentaconnect.com
Aflatoxins and ochratoxins are among the most important mycotoxins of all and producers of
both types of mycotoxins are present in Aspergillus section Flavi, albeit never in the same …

Next-generation sequencing approach for connecting secondary metabolites to biosynthetic gene clusters in fungi

RA Cacho, Y Tang, YH Chooi - Frontiers in microbiology, 2015 - frontiersin.org
Genomics has revolutionized the research on fungal secondary metabolite (SM)
biosynthesis. To elucidate the molecular and enzymatic mechanisms underlying the …

Biosynthesis of the halogenated mycotoxin aspirochlorine in koji mold involves a cryptic amino acid conversion

P Chankhamjon, D Boettger‐Schmidt… - Angewandte …, 2014 - Wiley Online Library
Abstract Aspirochlorine (1) is an epidithiodiketopiperazine (ETP) toxin produced from koji
mold (Aspergillus oryzae), which has been used in the oriental cuisine for over two …

Sensitive deep-sequencing-based HIV-1 genotyping assay to simultaneously determine susceptibility to protease, reverse transcriptase, integrase, and maturation …

RM Gibson, AM Meyer, D Winner, J Archer… - Antimicrobial agents …, 2014 - Am Soc Microbiol
With 29 individual antiretroviral drugs available from six classes that are approved for the
treatment of HIV-1 infection, a combination of different phenotypic and genotypic tests is …

Motif-Independent Prediction of a Secondary Metabolism Gene Cluster Using Comparative Genomics: Application to Sequenced Genomes of Aspergillus and Ten …

I Takeda, M Umemura, H Koike, K Asai… - DNA …, 2014 - academic.oup.com
Despite their biological importance, a significant number of genes for secondary metabolite
biosynthesis (SMB) remain undetected due largely to the fact that they are highly diverse …

Whole genome sequencing of the black grouse (Tetrao tetrix): reference guided assembly suggests faster-Z and MHC evolution

B Wang, R Ekblom, I Bunikis, H Siitari, J Höglund - BMC genomics, 2014 - Springer
Background The different regions of a genome do not evolve at the same rate. For example,
comparative genomic studies have suggested that the sex chromosomes and the regions …

Harnessing cross-species alignment to discover SNPs and generate a draft genome sequence of a bighorn sheep (Ovis canadensis)

JM Miller, SS Moore, P Stothard, X Liao, DW Coltman - BMC genomics, 2015 - Springer
Background Whole genome sequences (WGS) have proliferated as sequencing technology
continues to improve and costs decline. While many WGS of model or domestic organisms …

Diagnosis and management of invasive fungal diseases by next-generation sequencing: are we there yet?

NE Babady, CY Chiu, A Craney… - Expert Review of …, 2024 - Taylor & Francis
ABSTRACT Introduction Invasive fungal diseases (IFDs) are a serious threat to
immunocompromised patients. Routine diagnostic methods have limited performance in …

Motif-independent de novo detection of secondary metabolite gene clusters—toward identification from filamentous fungi

M Umemura, H Koike, M Machida - Frontiers in Microbiology, 2015 - frontiersin.org
Secondary metabolites are produced mostly by clustered genes that are essential to their
biosynthesis. The transcriptional expression of these genes is often cooperatively regulated …