Dysregulation in lipid metabolism is among the most prominent metabolic alterations in
cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological …

As competitive HMG-CoA reductase (HMGCR) inhibitors, statins not only reduce cholesterol
and improve cardiovascular risk, but also exhibit pleiotropic effects that are independent of …

Cholesterol metabolism produces essential membrane components as well as metabolites
with a variety of biological functions. In the tumour microenvironment, cell-intrinsic and cell …

Altered lipid metabolism is among the most prominent metabolic alterations in cancer.
Enhanced synthesis or uptake of lipids contributes to rapid cancer cell growth and tumor …

With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …

Cholesterol and its metabolites (precursors and derivatives) play an important role in cancer.
In recent years, numerous studies have reported the functions of cholesterol metabolism in …

Lipid droplets (also known as lipid bodies) are lipid-rich, cytoplasmic organelles that play
important roles in cell signaling, lipid metabolism, membrane trafficking, and the production …

Reprogramming of lipid metabolism is a newly recognized hallmark of malignancy.
Increased lipid uptake, storage and lipogenesis occur in a variety of cancers and contribute …

Genome-scale network reconstructions have helped uncover the molecular basis of
metabolism. Here we present Recon3D, a computational resource that includes three …

Ferroptosis, a new form of regulated cell death triggered by the iron-dependent peroxidation
of phospholipids, is associated with cellular metabolism, redox homeostasis, and various …