Type 1 diabetes mellitus is believed to result from destruction of the insulin-producing β-cells
in pancreatic islets that is mediated by autoimmune mechanisms. The classic view is that …

Type 1 diabetes is a chronic autoimmune disease characterised by insulin deficiency and
resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past …

We analyzed the effects of a single 14-day course of teplizumab treatment on metabolic
function and immune cells among participants in a previously reported randomized …

Objective Type 1 diabetes (T1D) is characterised by islet autoimmunity and beta cell
destruction. A gut microbiota–immunological interplay is involved in the pathophysiology of …

Background Type 1 diabetes is a chronic autoimmune disease that leads to destruction of
insulin-producing beta cells and dependence on exogenous insulin for survival. Some …

Type 1 diabetes (T1D) is an autoimmune disease in which T cells attack and destroy the
insulin-producing β cells in the pancreatic islets. Genetic and environmental factors increase …

Type 1 diabetes mellitus (T1DM), also known as autoimmune diabetes, is a chronic disease
characterized by insulin deficiency due to pancreatic β-cell loss and leads to …

Type 1 diabetes is an autoimmune disease caused by the immune-mediated destruction of
pancreatic β cells that results in lifelong absolute insulin deficiency. For nearly a century …

Over the past decade, knowledge of the pathogenesis and natural history of type 1 diabetes
has grown substantially, particularly with regard to disease prediction and heterogeneity …

Restoration of insulin independence and normoglycemia has been the overarching goal in
diabetes research and therapy. While whole-organ and islet transplantation have become …