Dual HER2 inhibition: mechanisms of synergy, patient selection, and resistance

AG Waks, O Martínez-Sáez, P Tarantino… - Nature Reviews …, 2024 - nature.com
HER2-targeted therapies for patients with HER2+ breast cancer are rapidly evolving,
offering a range of more complex and personalized treatment options. Currently, an array of …

[HTML][HTML] Application and challenge of HER2DX genomic assay in HER2+ breast cancer treatment

S Ma, Y Zhou, D Ma, X Qi… - American Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
HER2-positive breast cancer is highly aggressive, with a significant risk of recurrence and
metastasis, leading to a poor prognosis. While most early-stage HER2-positive breast …

HER2DX genomic assay in HER2-positive early breast cancer treated with trastuzumab and pertuzumab: a correlative analysis from the PHERGain phase II trial

A Llombart-Cussac, J Pérez-García… - Clinical Cancer …, 2024 - aacrjournals.org
Purpose: The purpose of this study was to assess the predictive capability of HER2DX assay
following (neo) adjuvant trastuzumab–pertuzumab (HP)–based therapy in HER2-positive …

Survival outcomes of neoadjuvant versus adjuvant therapy in patients with T1c, node‐negative, human epidermal growth factor receptor 2–positive breast cancer: A …

X Wang, Y Shang, J Zhang, J Liu, Z Fang, Y Liu… - Cancer, 2024 - Wiley Online Library
Background Persistent debates exist regarding the superiority of neoadjuvant therapy (NAT)
over adjuvant therapy (AT) for patients with T1c, node‐negative, human epidermal growth …

A 14-gene B-cell immune signature in early-stage triple-negative breast cancer (TNBC): a pooled analysis of seven studies

B Conte, F Brasó-Maristany, AR Hernández… - …, 2024 - thelancet.com
Background Early-stage triple-negative breast cancer (TNBC) displays clinical and
biological diversity. From a biological standpoint, immune infiltration plays a crucial role in …

Predicting pathologic complete response to neoadjuvant chemotherapy in breast cancer using a machine learning approach

F Zhao, E Polley, J McClellan, F Howard… - Breast Cancer …, 2024 - Springer
Background For patients with breast cancer undergoing neoadjuvant chemotherapy (NACT),
most of the existing prediction models of pathologic complete response (pCR) using …

Molecular Characterization and Classification of HER2-Positive Breast Cancer Inform Tailored Therapeutic Strategies

YW Li, LJ Dai, XR Wu, S Zhao, YZ Xu, X Jin… - Cancer …, 2024 - aacrjournals.org
HER2-positive breast cancer is an aggressive subtype that accounts for 15% to 20% of all
breast cancers. Recent studies have suggested that HER2-positive breast cancer is a group …

Unveiling Neoadjuvant Therapy: Insights and Outlooks for HER2-Positive Early Breast Cancer

H Bischoff, M Espié, T Petit - Current Treatment Options in Oncology, 2024 - Springer
Opinion Statement This perspective underscores the evolution and significance of
neoadjuvant therapy in breast cancer, tracing its history and efficacy in improving outcomes …

[HTML][HTML] De-Escalating Treatment Strategies for Patients with Human Epidermal Growth Factor Receptor-2 (HER2)-Positive Early-Stage Breast Cancer

H Abdel-Razeq - Cancers, 2024 - mdpi.com
Simple Summary Almost one in five patients with breast cancer have an aggressive subtype
that expresses Human Epidermal Growth Factor-2 (HER2) receptor. The introduction of anti …

[HTML][HTML] Administration sequences in single-day chemotherapy regimens for breast cancer: a comprehensive review from a practical perspective

M Wu, X Huang, M Chen, Y Zhang - Frontiers in Oncology, 2024 - pmc.ncbi.nlm.nih.gov
Introduction Breast cancer is one of the most prevalent malignant tumors globally, posing a
severe threat to human life and health. Chemotherapy, a cornerstone in the treatment of …