Cell motility is essential for life and development. Unfortunately, cell migration is also linked
to several pathological processes, such as cancer metastasis. Cells' ability to migrate relies …

Collagen is one of the most abundant proteins in animals and a major component of the
extracellular matrix (ECM) in tissues. Besides playing a role as a structural building block of …

Invasive cells use transient, energy-consuming protrusions to breach basement membrane
(BM) barriers. Using the ATP sensor PercevalHR during anchor cell (AC) invasion in …

The role of metabolism in tumor growth and chemoresistance has received considerable
attention, however, the contribution of mitochondrial bioenergetics in migration, invasion …

Cell function relies on the spatiotemporal dynamics of metabolic reactions. In all
physiopathological processes of tissues, mechanical forces impact the structure and function …

Tumours are heterogeneous tissues containing diverse populations of cells and an
abundant extracellular matrix (ECM). This tumour microenvironment prompts cancer cells to …

Simple Summary Mitochondria are essential cellular organelles, involved in controlling
energy production, cell metabolism, cell growth, and cell death. Since cellular functions are …

To form blood vessels, endothelial cells rearrange their cytoskeleton, generate traction
stresses, migrate, and proliferate, all of which require energy. Despite these energetic costs …

Spheroids are widely used in vitro 3D multicellular model systems that mimic complex
physiological microenvironments of tissues. As different cell types vary in deformability and …

The mechanical properties of solid tumors influence tumor cell phenotype and the ability to
invade surrounding tissues. Using bioengineered scaffolds to provide a matrix …