Vascular dementia (VaD) is the second most common type of dementia after Alzheimer's
disease (AD), characterized by progressive cognitive impairment, memory loss, and thinking …

Given the complexities of the mammalian CNS, its regeneration is viewed as the holy grail of
regenerative medicine. Extraordinary efforts have been made to understand developmental …

Cellular senescence is a form of adaptive cellular physiology associated with aging. Cellular
senescence causes a proinflammatory cellular phenotype that impairs tissue regeneration …

Oligodendrocytes (OLGs) are generated late in development and myelination is thus a
tardive event in the brain developmental process. It is however maintained whole life long at …

Enhancing repair of myelin is an important but still elusive therapeutic goal in many
neurological disorders. In multiple sclerosis, an inflammatory demyelinating disease …

Amongst neurological diseases, multiple sclerosis (MS) presents an attractive target for
regenerative medicine. This is because the primary pathology, the loss of myelin‐forming …

The basic helix-loop-helix transcription factor Olig2 is a key determinant for the specification
of neural precursor cells into oligodendrocyte progenitor cells. However, the functional role …

Highlights•Secreted signals regulate OPC specification during development and in the
adult.•OL differentiation is controlled by chromatin remodeling and transcription …

Neural stem cells in the subventricular zone (SVZ) of the lateral ventricle of adult rodent
brain generate oligodendrocyte progenitor cells (OPCs) that disperse throughout the corpus …

Remyelination therapies, which are currently under development, have a great potential to
delay, prevent or even reverse disability in multiple sclerosis patients. Several models are …