Calcium channels in the development, maturation, and function of spermatozoa

A Darszon, T Nishigaki, C Beltran… - Physiological …, 2011 - journals.physiology.org
A proper dialogue between spermatozoa and the egg is essential for conception of a new
individual in sexually reproducing animals. Ca2+ is crucial in orchestrating this unique event …

The CAP superfamily: cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins—roles in reproduction, cancer, and immune defense

GM Gibbs, K Roelants, MK O'bryan - Endocrine reviews, 2008 - academic.oup.com
The cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP)
superfamily members are found in a remarkable range of organisms spanning each of the …

All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility

H Qi, MM Moran, B Navarro… - Proceedings of the …, 2007 - National Acad Sciences
Mammalian spermatozoa become motile at ejaculation, but before they can fertilize the egg,
they must acquire more thrust to penetrate the cumulus and zona pellucida. The forceful …

Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel

Y Kirichok, B Navarro, DE Clapham - Nature, 2006 - nature.com
In mammals, sperm cells become motile during ejaculation and swim up the female
reproductive tract. Before fertilization and to overcome various barriers, their motility must be …

[HTML][HTML] Ca2+-stores in sperm: their identities and functions

S Costello, F Michelangeli, K Nash… - Reproduction …, 2009 - ncbi.nlm.nih.gov
Intracellular Ca 2+ stores play a central role in the regulation of cellular [Ca 2+] i and the
generation of complex [Ca 2+] signals such as oscillations and waves. Ca 2+ signalling is of …

[Ca2+]i signalling in sperm — making the most of what you've got

S Publicover, CV Harper, C Barratt - Nature cell biology, 2007 - nature.com
Thanks to a worrying decrease in male fertility, understanding how sperm'work'is a matter
both of interest and great importance. Sperm of all animals detect various environmental …

Ca2+ signaling in mammalian spermatozoa

M Finkelstein, N Etkovitz, H Breitbart - Molecular and Cellular …, 2020 - Elsevier
Calcium is an essential ion which regulates sperm motility, capacitation and the acrosome
reaction (AR), three processes necessary for successful fertilization. The AR enables the …

Sperm channel diversity and functional multiplicity

A Darszon, JJ Acevedo, BE Galindo… - …, 2006 - rep.bioscientifica.com
Ion channels are extraordinarily efficient machines that move ions in diversely controlled
manners, allowing cells to rapidly exchange information with the outside world and with …

Molecular mechanism for human sperm chemotaxis mediated by progesterone

ME Teves, HA Guidobaldi, DR Unates, R Sanchez… - PloS one, 2009 - journals.plos.org
Sperm chemotaxis is a chemical guiding mechanism that may orient spermatozoa to the egg
surface. A picomolar concentration gradient of Progesterone (P), the main steroidal …

CatSper calcium channels: 20 years on

JY Hwang, JJ Chung - Physiology, 2023 - journals.physiology.org
The flagellar-specific Ca2+ channel CatSper is the predominant Ca2+ entry site in
mammalian sperm. CatSper-mediated Ca2+ signaling affects nearly every event that …