Carvedilol is an arylethanolamine that is a racemic mixture of 2 enantiomers. The S-(−)-
enantiomer has β-adrenoceptor blocking activity, while the racemate also has α 1-receptor …

Synopsis Carvedilol is a β-adrenoceptor antagonist which also causes peripheral
vasodilation primarily via α 1-adrenergic blockade. Carvedilol produces its antihypertensive …

Synopsis Carvedilol competitively blocks β 1, β 2 and α 1 receptors. The drug lacks
sympathomimetic activity and has vasodilating properties that are exerted primarily through …

Objective: The aryloxypropanolamine carvedilol is a multiple action cardiovascular drug with
blocking effects on α-receptors, β-receptors, Ca2+-channels, Na+-channels and various …

Carvedilol (Dilatrend®) blocks β 1-, β 2-and α 1-adrenoceptors, and has antioxidant and
antiproliferative effects. Carvedilol improved left ventricular ejection fraction (LVEF) in …

Carvedilol ((±)-1-(carbazol-4-yloxy)-3-[[2-(o-methoxyphenoxy) ethyl] amino]-2-propanol), a β-
adrenoceptor-blocking agent with vasodilator properties, has been reported to produce dose …

Effective and safe pharmacological management of cardiac arrhythmia still constitutes a
major clinical challenge. Outward potassium currents mediated by two-pore-domain …

Background and Purpose The β‐receptor antagonist carvedilol blocks a range of ion
channels. K2P 2.1 (TREK1) and K2P 10.1 (TREK2) channels are expressed in the heart and …

Beta-adrenergic stimulation and the resultant Ca2+ load both seem to be associated with
progression of heart failure as well as hypertrophy. Because theα1-, β1, 2-blocker …

An increasing number of elderly patients are exposed to cardiovascular drugs for the
treatment of acute and/or chronic conditions. This is a result of the progressive aging of the …