Sepsis-associated encephalopathy

TE Gofton, GB Young - Nature Reviews Neurology, 2012 - nature.com
Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction that occurs
secondary to infection in the body without overt CNS infection. SAE is frequently …

The spectrum of sepsis-associated encephalopathy: a clinical perspective

R Sonneville, S Benghanem, L Jeantin… - Critical Care, 2023 - Springer
Sepsis-associated encephalopathy is a severe neurologic syndrome characterized by a
diffuse dysfunction of the brain caused by sepsis. This review provides a concise overview of …

HMGB1 mediates synaptic loss and cognitive impairment in an animal model of sepsis-associated encephalopathy

XY Yin, XH Tang, SX Wang, YC Zhao, M Jia… - Journal of …, 2023 - Springer
Background Microglial activation-mediated neuroinflammation is one of the essential
pathogenic mechanisms of sepsis-associated encephalopathy (SAE). Mounting evidence …

Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit

EW Ely, A Shintani, B Truman, T Speroff, SM Gordon… - Jama, 2004 - jamanetwork.com
ContextIn the intensive care unit (ICU), delirium is a common yet underdiagnosed form of
organ dysfunction, and its contribution to patient outcomes is unclear. ObjectiveTo determine …

The impact of delirium in the intensive care unit on hospital length of stay

E Ely, S Gautam, R Margolin, J Francis, L May… - Intensive care …, 2001 - Springer
Study objective: To determine the relationship between delirium in the intensive care unit
(ICU) and outcomes including length of stay in the hospital. Design: A prospective cohort …

Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients

P Pandharipande, A Shintani, J Peterson… - The Journal of the …, 2006 - pubs.asahq.org
Background Delirium has recently been shown as a predictor of death, increased cost, and
longer duration of stay in ventilated patients. Sedative and analgesic medications relieve …

[HTML][HTML] Impact of acute kidney injury on distant organ function: recent findings and potential therapeutic targets

K Doi, H Rabb - Kidney international, 2016 - Elsevier
Acute kidney injury (AKI) is a common complication in critically ill patients and subsequently
worsens outcomes. Although many drugs to prevent and treat AKI have shown benefits in …

The spectrum of septic encephalopathy: definitions, etiologies, and mortalities

LA Eidelman, D Putterman, C Putterman, CL Sprung - Jama, 1996 - jamanetwork.com
Objective.—To determine whether the severity of septic encephalopathy is correlated with
gram-negative bacteremia and mortality and whether there exists a single or combination of …

Sepsis associated encephalopathy

N Chaudhry, AK Duggal - Advances in medicine, 2014 - Wiley Online Library
Sepsis associated encephalopathy (SAE) is a common but poorly understood neurological
complication of sepsis. It is characterized by diffuse brain dysfunction secondary to infection …

Continuous electroencephalography in the medical intensive care unit

M Oddo, E Carrera, J Claassen, SA Mayer… - Critical care …, 2009 - journals.lww.com
Objectives: To examine predictors and the prognostic value of electrographic seizures
(ESZs) and periodic epileptiform discharges (PEDs) in medical intensive care unit (MICU) …