Cancer-associated fibroblasts (CAFs) are one of the most significant components in the
tumour microenvironment (TME), where they can perform several protumourigenic functions …

This review deals with the roles of calcium ions and ATP in the control of the normal
functions of the different cell types in the exocrine pancreas as well as the roles of these …

Pancreatic ductal adenocarcinoma (PDAC) is one of the five most lethal malignancies
worldwide and survival has not improved substantially in the past 30 years. Desmoplasia …

Pancreatic ductal adenocarcinoma is a devastating disease, and patient outcomes have not
improved in decades. Treatments that target tumor cells have largely failed. This could be …

Obesity increases the risk of adverse outcomes during acute critical illnesses such as burns,
severe trauma, and acute pancreatitis. Although individuals with more body fat and higher …

The field of pancreatic stellate cell (PSC) biology is very young, as the essential invitro tools
to study these cells (ie, methods to isolate and culture PSC) were only developed as recently …

While the morphology and function of cells of the exocrine and endocrine pancreas have
been studied over several centuries, one important cell type in the gland, the pancreatic …

Pancreatic stellate cells (PSCs) were identified in the early 1980s, but received much
attention after 1998 when the methods to isolate and culture them from murine and human …

Cholinergic degeneration is significant in Lewy body disease, including Parkinson's
disease, dementia with Lewy bodies, and isolated REM sleep behaviour disorder. Extensive …

Pancreatic stellate cells, normally quiescent, are capable of remarkable transition into their
activated myofibroblast-like phenotype. It is now commonly accepted that these cells play a …