Kaposi sarcoma (KS) gained public attention as an AIDS-defining malignancy; its
appearance on the skin was a highly stigmatizing sign of HIV infection during the height of …

Since the discovery of interferon 50years ago a great deal of progress has been made in
understanding how interferons work and how and why they are induced. Key factors in …

IL-28 and IL-29 were recently described as members of a new cytokine family that shares
with type I interferon (IFN) the same Jak/Stat signalling pathway driving expression of a …

ABSTRACT K3/MIR1 and K5/MIR2 of Kaposi's sarcoma-associated herpesvirus (KSHV) are
viral members of the membrane-associated RING-CH (MARCH) ubiquitin ligase family and …

Kaposi sarcoma herpesvirus (KSHV), taxonomical name human gammaherpesvirus 8, is a
phylogenetically old human virus that co-evolved with human populations, but is now only …

Kaposi's sarcoma-associated herpesvirus (KSHV; also known as human herpesvirus 8) is
the etiologic agent of Kaposi's sarcoma, primary effusion lymphoma, and multicentric …

Abstract Interferon lambda-1 (IFN-λ1/IL-29) is a member of the Type-III interferon family,
which contains three ligands: IFN-λ1, 2 and 3. These three ligands use the same unique …

Multicentric Castleman disease (MCD) encompasses a spectrum of conditions that give rise
to overlapping clinicopathological manifestations. The fundamental pathogenetic …

Virus infection triggers interferon (IFN)-mediated innate immune defenses in part through
viral nucleic acid interactions. However, the immune recognition mechanisms by which the …

Highlights•KSHV/HHV8 causes three human diseases: Kaposi Sarcoma, Primary Effusion
Lymphoma and the plasma cell variant of Multicentric Castleman Disease.•These occur …