Initially, gene therapy was viewed as an approach for treating hereditary diseases, but its
potential role in the treatment of acquired diseases such as cancer is now widely …

As a consequence of several setbacks encountered by viral technology in achieving efficient
and safe gene therapy in clinical trials, non-viral gene delivery vectors are considered to …

Lipoplexes and polyplexes are widely applied as nonviral gene delivery carriers. Although
their efficiencies of transfection are comparable, their mechanisms of delivery, specifically at …

Nanotechnology is a multidisciplinary field that covers a vast and diverse array of devices
and machines derived from engineering, physics, materials science, chemistry and biology …

We report the rational design of multifunctional nanoparticles for short-interfering RNA
(siRNA) delivery and imaging based on the use of semiconductor quantum dots (QDs) and …

Cationic lipid-mediated gene transfer is widely used for their advantages over viral gene
transfer because it is non-immunogenic, easy to produce and not oncogenic. The main …

DNA transport through the cell membrane is an essential requirement for gene therapy,
which utilizes oligonucleotides and plasmid DNA. However, membrane transport of DNA is …

RNA interference (RNAi) represents a powerful method for specific gene silencing. It is
mediated through small double-stranded RNA molecules (small interfering RNAs, siRNAs) …

Synthetic amphiphiles are widely used as a carrier system. However, to match transfection
efficiencies as obtained for viral vectors, further insight is required into the properties of …

Cationic lipid-and polymer-based nanodevices are considered appropriate alternatives for
virus-based particles for delivery of nucleic acids, including genes and siRNA, into …