Bone development and bone remodelling during adult life are highly anabolic processes
requiring an adequate supply of oxygen and nutrients. Bone-forming osteoblasts and bone …

Osteoarthritis (OA) is a complex disease of whole joints with progressive cartilage matrix
degradation and chondrocyte transformation. The inflammatory features of OA are reflected …

Disorders of chondrocyte differentiation and endochondral osteogenesis are major
underlying factors in skeletal developmental disorders, including tibial dysplasia (TD) …

Endochondral ossification (ECO), the major ossification process during embryogenesis and
bone repair, involves the formation of a cartilaginous template remodelled into a functional …

Transforming growth factor (TGF)-β1 is a multifunctional protein that is essential in many
cellular processes that include fibrosis, inflammation, chondrogenesis, and cartilage repair …

Chondrocytes in the resting zone of the postnatal growth plate are characterized by slow cell
cycle progression, and encompass a population of parathyroid hormone-related protein …

The cranial base is formed by endochondral ossification and functions as a driver of
anteroposterior cranial elongation and overall craniofacial growth. The cranial base contains …

Hypertrophic chondrocytes are found at unique locations at the junction of skeletal tissues,
cartilage growth plate, articular cartilage, enthesis and intervertebral discs. Their role in the …

At the very moment of cell-cycle arrest, the cell is not senescent yet. For several days in cell
culture, the arrested cell is acquiring a senescent phenotype. What is happening during this …

Non-homologous chromosomal contacts (NHCCs) between different chromosomes
participate considerably in gene and genome regulation. Due to analytical challenges …