The how and why of lncRNA function: an innate immune perspective

EK Robinson, S Covarrubias, S Carpenter - Biochimica et Biophysica Acta …, 2020 - Elsevier
Next-generation sequencing has provided a more complete picture of the composition of the
human transcriptome indicating that much of the “blueprint” is a vastness of poorly …

MicroRNA and transcription factor: key players in plant regulatory network

AFA Samad, M Sajad, N Nazaruddin, IA Fauzi… - Frontiers in plant …, 2017 - frontiersin.org
Recent achievements in plant microRNA (miRNA), a large class of small and non-coding
RNAs, are very exciting. A wide array of techniques involving forward genetic, molecular …

Evolutionary constraint and innovation across hundreds of placental mammals

MJ Christmas, IM Kaplow, DP Genereux, MX Dong… - Science, 2023 - science.org
Zoonomia is the largest comparative genomics resource for mammals produced to date. By
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …

HOCOMOCO: towards a complete collection of transcription factor binding models for human and mouse via large-scale ChIP-Seq analysis

IV Kulakovskiy, IE Vorontsov, IS Yevshin… - Nucleic acids …, 2018 - academic.oup.com
We present a major update of the HOCOMOCO collection that consists of patterns
describing DNA binding specificities for human and mouse transcription factors. In this …

[HTML][HTML] CiiiDER: A tool for predicting and analysing transcription factor binding sites

LJ Gearing, HE Cumming, R Chapman, AM Finkel… - PloS one, 2019 - journals.plos.org
The availability of large amounts of high-throughput genomic, transcriptomic and
epigenomic data has provided opportunity to understand regulation of the cellular …

Combined Analysis of the Fruit Metabolome and Transcriptome Reveals Candidate Genes Involved in Flavonoid Biosynthesis in Actinidia arguta

Y Li, J Fang, X Qi, M Lin, Y Zhong, L Sun… - International journal of …, 2018 - mdpi.com
To assess the interrelation between the change of metabolites and the change of fruit color,
we performed a combined metabolome and transcriptome analysis of the flesh in two …

The forkhead-box family of transcription factors: key molecular players in colorectal cancer pathogenesis

P Laissue - Molecular cancer, 2019 - Springer
Colorectal cancer (CRC) is the third most commonly occurring cancer worldwide and the
fourth most frequent cause of death having an oncological origin. It has been found that …

Genomic repeats categorize genes with distinct functions for orchestrated regulation

JY Lu, W Shao, L Chang, Y Yin, T Li, H Zhang, Y Hong… - Cell reports, 2020 - cell.com
Repetitive elements are abundantly distributed in mammalian genomes. Here, we reveal a
striking association between repeat subtypes and gene function. SINE, L1, and low …

Stress induced aging in mouse eye

Q Xu, C Rydz, VA Nguyen Huu, L Rocha… - Aging …, 2022 - Wiley Online Library
Aging, a universal process that affects all cells in an organism, is a major risk factor for a
group of neuropathies called glaucoma, where elevated intraocular pressure is one of the …

PWM2Vec: An efficient embedding approach for viral host specification from coronavirus spike sequences

S Ali, B Bello, P Chourasia, RT Punathil, Y Zhou… - Biology, 2022 - mdpi.com
Simple Summary The family of coronaviruses comprises a diverse set of strains and variants
which cause diseases from the common cold to COVID-19. Moreover, they infect a wide …