Lipids constitute the bulk of the dry mass of the brain and have been associated with healthy
function as well as the most common pathological conditions of the brain. Demographic …

Alzheimer's disease (AD) is the leading cause of dementia worldwide. Individuals affected
by the disease gradually lose their capacity for abstract thinking, understanding …

Late-onset Alzheimer's disease (LOAD) is the most common multifactorial
neurodegenerative disease among elderly people. LOAD is heterogeneous, and the …

Apolipoprotein C1 (apoC1), the smallest of all apolipoproteins, participates in lipid transport
and metabolism. In humans, APOC1 gene is in linkage disequilibrium with APOE gene on …

Mitochondria play an important role in numerous processes, including energy generation,
regulating ion homeostasis, and cell signaling. Mitochondria are also the main source of …

Redox post-translational modifications are derived from fluctuations in the redox potential
and modulate protein function, localization, activity and structure. Amongst the oxidative …

Background Increasing evidence implicates oxidative stress (OS) in Alzheimer disease (AD)
and mild cognitive impairment (MCI). Depletion of the brain antioxidant glutathione (GSH) …

Background Potential links between oxidative stress and the pathophysiology of Alzheimer's
disease (AD) have been reported in the existing literature. Biological markers of oxidative …

It is estimated that the impact of related genes on the risk of Alzheimer's disease (AD) is
nearly 70%. Identifying candidate causal genes can help treatment and diagnosis. The …

Neurological diseases can be broadly divided according to causal factors into circulatory
system disorders leading to ischemic stroke; degeneration of the nerve cells leading to …