A review: Methodologies to promote the differentiation of mesenchymal stem cells for the regeneration of intervertebral disc cells following intervertebral disc …

T Ohnishi, K Homan, A Fukushima, D Ukeba, N Iwasaki… - Cells, 2023 - mdpi.com
Intervertebral disc (IVD) degeneration (IDD), a highly prevalent pathological condition
worldwide, is widely associated with back pain. Treatments available compensate for the …

Targeted mitochondrial nanomaterials in biomedicine: Advances in therapeutic strategies and imaging modalities

Z Chen, L Chen, T dong Lyu, S Weng, Y Xie, Y Jin… - Acta Biomaterialia, 2024 - Elsevier
Mitochondria, pivotal organelles crucial for energy generation, apoptosis regulation, and
cellular metabolism, have spurred remarkable advancements in targeted material …

Enhanced mitochondrial targeting and inhibition of pyroptosis with multifunctional metallopolyphenol nanoparticles in intervertebral disc degeneration

H Zhou, Q Qian, Q Chen, T Chen, C Wu, L Chen… - Small, 2024 - Wiley Online Library
Intervertebral disc degeneration (IVDD) is a significant contributor to low back pain,
characterized by excessive reactive oxygen species generation and inflammation‐induced …

Rescuing Nucleus Pulposus Cells from ROS Toxic Microenvironment via Mitochondria‐Targeted Carbon Dot‐Supported Prussian Blue to Alleviate Intervertebral Disc …

Y Shi, W Bu, D Chu, W Lin, K Li… - Advanced …, 2024 - Wiley Online Library
Intervertebral disc degeneration (IVDD) is invariably accompanied by excessive
accumulation of reactive oxygen species (ROS), resulting in progressive deterioration of …

[HTML][HTML] A ROS-responsive hydrogel incorporated with dental follicle stem cell-derived small extracellular vesicles promotes dental pulp repair by ameliorating …

M Li, J Tian, K Yu, H Liu, X Yu, N Wang, Q Gong, K Li… - Bioactive Materials, 2024 - Elsevier
Pulpitis, an inflammatory disease of dental pulp tissues, ultimately results in the loss of pulp
defense properties. Existing clinical modalities cannot effectively promote inflamed pulp …

Natural dietary ROS scavenger-based nanomaterials for ROS-related chronic disease prevention and treatment

J Xie, R Dong, T Zhang, F Guo, H Li, X Chen… - Chemical Engineering …, 2024 - Elsevier
Growing evidence demonstrates that reactive oxygen species (ROS) is closely related to
many chronic disease progressions, such as atherosclerosis and rheumatoid arthritis …

SEPHS1 attenuates intervertebral disc degeneration by delaying nucleus pulposus cell senescence through the Hippo-Yap/Taz pathway

T Hu, Z Shi, Y Sun, F Hu, Y Rong… - … of Physiology-Cell …, 2024 - journals.physiology.org
Nucleus pulposus cell (NPC) senescence is a major cause of intervertebral disc
degeneration (IVDD). Oxidative stress and reactive oxygen species (ROS) play critical roles …

[HTML][HTML] Screening strategy identified idebenone loaded ROS-responsive nano-polyphenolic vesicle for spinal cord injury therapy

C Wu, X Chen, X Zhao, Y Chen, H Zhou, Y Deng, C Li… - Materials & Design, 2024 - Elsevier
Spinal cord injury (SCI) is a severe central nerve diseases which lacks effective of treatment.
Oxidative stress is a major pathological factor for SCI. It may induce mitochondrial damage …

[HTML][HTML] Role of oxidative stress in mitochondrial dysfunction and their implications in intervertebral disc degeneration: Mechanisms and therapeutic strategies

H Zhou, C Wu, Y Jin, O Wu, L Chen, Z Guo… - Journal of Orthopaedic …, 2024 - Elsevier
Background Intervertebral disc degeneration (IVDD) is widely recognized as one of the
leading causes of low back pain. Intervertebral disc cells are the main components of the …

Laquinimod attenuates oxidative stress-induced mitochondrial injury and alleviates intervertebral disc degeneration by inhibiting the NF-κB signaling pathway

H Xiao, K Wang, L Peng, Z Yin - International Immunopharmacology, 2024 - Elsevier
Background Low back pain (LBP) caused by intervertebral disc degeneration (IVDD) is a
significant global health concern. It is necessary to investigate the underlying pathological …