Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

Exercise is fundamental for good health, whereas physical inactivity underpins many chronic
diseases of modern society. It is well appreciated that regular exercise improves metabolism …

Few physiological parameters are more tightly and acutely regulated in humans than blood
glucose concentration. The major cellular mechanism that diminishes blood glucose when …

For decades, exercise has been consid-ered a cornerstone of diabetes management, along
with diet and medication. However, high-quality evidence on the importance of exercise and …

Chronic contractile activity produces mitochondrial biogenesis in muscle. This adaptation
results in a significant shift in adenine nucleotide metabolism, with attendant improvements …

The pattern of muscle glycogen synthesis following glycogen-depleting exercise occurs in
two phases. Initially, there is a period of rapid synthesis of muscle glycogen that does not …

Skeletal muscle shows an enormous plasticity to adapt to stimuli such as contractile activity
(endurance exercise, electrical stimulation, denervation), loading conditions (resistance …

Glycogen is a branched polymer of glucose which serves as a reservoir of glucose units.
The two largest deposits in mammals are in the liver and skeletal muscle but many cells are …

OBJECTIVE—Insulin resistance associated with obesity and diabetes is ameliorated by
specific overexpression of GLUT4 in skeletal muscle. The molecular mechanisms regulating …

Exercise training elicits a number of adaptive changes in skeletal muscle that result in an
improved metabolic efficiency. The molecular mechanisms mediating the cellular …