Osteosarcoma overview

BA Lindsey, JE Markel, ES Kleinerman - Rheumatology and therapy, 2017 - Springer
Osteosarcoma (OS) is the most common primary malignancy of bone and patients with
metastatic disease or recurrences continue to have very poor outcomes. Unfortunately, little …

Germline and somatic genetics of osteosarcoma—connecting aetiology, biology and therapy

DM Gianferante, L Mirabello, SA Savage - Nature Reviews …, 2017 - nature.com
Clinical outcomes and treatment modalities for osteosarcoma, the most common primary
cancer of bone, have changed very little over the past 30 years. The peak incidence of …

Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics

S Simpson, MD Dunning, S de Brot… - Acta Veterinaria …, 2017 - Springer
Osteosarcoma (OSA) is a rare cancer in people. However OSA incidence rates in dogs are
27 times higher than in people. Prognosis in both species is relatively poor, with 5 year OSA …

Animal models and therapeutic molecular targets of cancer: utility and limitations

M Cekanova, K Rathore - Drug design, development and therapy, 2014 - Taylor & Francis
Cancer is the term used to describe over 100 diseases that share several common
hallmarks. Despite prevention, early detection, and novel therapies, cancer is still the …

Breed‐predispositions to cancer in pedigree dogs

JM Dobson - International Scholarly Research Notices, 2013 - Wiley Online Library
Cancer is a common problem in dogs and although all breeds of dog and crossbred dogs
may be affected, it is notable that some breeds of pedigree dogs appear to be at increased …

Consensus regarding the diagnosis, prognosis and treatment of canine and feline mammary tumors-2019

GD Cassali, PC Jark, C Gamba, KA Damasceno… - 2020 - arca.fiocruz.br
The aim of this paper is to discuss and update criteria that can guide the diagnosis,
prognosis and treatment of canine and feline mammary neoplasms. It was elaborated during …

Dog models of naturally occurring cancer

JL Rowell, DO McCarthy, CE Alvarez - Trends in molecular medicine, 2011 - cell.com
Studies using dogs provide an ideal solution to the gap in animal models for natural disease
and translational medicine. This is evidenced by approximately 400 inherited disorders …

Canine osteosarcoma: a naturally occurring disease to inform pediatric oncology

JM Fenger, CA London, WC Kisseberth - ILAR journal, 2014 - academic.oup.com
Osteosarcoma (OSA) is the most common form of malignant bone cancer in children and
dogs, although the disease occurs in dogs approximately 10 times more frequently than in …

2019 AAHA canine life stage guidelines

KE Creevy, J Grady, SE Little… - Journal of the …, 2019 - meridian.allenpress.com
The guidelines are an update and extension of the AAHA Canine Life Stage Guidelines
published in 2012. A noteworthy change from the earlier guidelines is the division of the …

Long-term health effects of neutering dogs: comparison of Labrador Retrievers with Golden Retrievers

BL Hart, LA Hart, AP Thigpen, NH Willits - PloS one, 2014 - journals.plos.org
Our recent study on the effects of neutering (including spaying) in Golden Retrievers in
markedly increasing the incidence of two joint disorders and three cancers prompted this …