Glioblastoma multiforme (GBM) may be one of the most challenging brain tumors to treat, as
patients generally do not live more than 2 years. This review aimed to give a timely review of …

Integral membrane proteins play key functional roles at organelles and the plasma
membrane, necessitating their efficient and accurate biogenesis to ensure appropriate …

The endoplasmic reticulum (ER) supports biosynthesis of proteins with diverse
transmembrane domain (TMD) lengths and hydrophobicity. Features in transmembrane …

The eukaryotic endoplasmic reticulum (ER) membrane contains essential complexes that
oversee protein biogenesis and lipid metabolism, impacting nearly all aspects of cell …

The endoplasmic reticulum (ER) membrane protein complex (EMC) is a key contributor to
biogenesis and membrane integration of transmembrane proteins, but our understanding of …

Brain tumors are common malignancies with high mortality and morbidity in which
glioblastoma (GB) is a grade IV astrocytoma with heterogeneous nature. The conventional …

Looking at the variety of the thousands of different polypeptides that have been focused on
in the research on the endoplasmic reticulum from the last five decades taught us one …

Defective rhodopsin homeostasis is one of the major causes of retinal degeneration,
including the disease Retinitis pigmentosa. To identify cellular factors required for the …

Background Lung adenocarcinoma (LUAD), the predominant subtype of non-small cell lung
cancer (NSCLC), remains a pervasive global public health concern. Disulfidoptosis, a …

Abstract Treatment of acute pancreatitis (AP) and chronic pancreatitis (CP) remains
problematic due to a lack of knowledge about disease-specific regulatory targets and …