Sickle cell disease (SCD) is a group of inherited disorders caused by mutations in HBB,
which encodes haemoglobin subunit β. The incidence is estimated to be between 300,000 …

Sickle cell disease (SCD) is an inherited blood disorder most common among African
American and Hispanic American persons. The disease can cause substantial, long-term …

Sickle cell disease (SCD) is a genetic disorder, characterized by hemolytic anemia and vaso‐
occlusive crises (VOCs). Data on the global SCD impact on quality of life (QoL) from the …

Study objective We provide an updated assessment of trends in sickle cell disease (SCD)–
related mortality, a significant source of mortality in the United States among black persons …

Importance Individuals with sickle cell disease (SCD) have reduced life expectancy;
however, there are limited data available on lifetime income in patients with SCD. Objective …

Thalassemia major and sickle cell disease are the two most widely disseminated hereditary
hemoglobinopathies in the world. The outlook for affected individuals has improved in recent …

In this study, the relationship of clinical differences among patients with sickle cell disease
(SCD) was examined to understand the major contributors to early mortality in a …

Genetic diseases of blood cells are prime candidates for treatment through ex vivo gene
editing of CD34+ hematopoietic stem/progenitor cells (HSPCs), and a variety of …

The aim of this prospective study was to evaluate the long-term efficacy and safety of
hydroxyurea (HU) in patients with sickle cell disease (SCD). Thirty-four patients with sickle …

Over the past 40 years, public health measures such as universal newborn screening,
penicillin prophylaxis, vaccinations, and hydroxyurea therapy have led to an impressive …