Emerging landscape of molecular interaction networks: Opportunities, challenges and prospects

G Panditrao, R Bhowmick, C Meena, RR Sarkar - Journal of Biosciences, 2022 - Springer
Network biology finds application in interpreting molecular interaction networks and
providing insightful inferences using graph theoretical analysis of biological systems. The …

Mechanism-centric approaches for biomarker detection and precision therapeutics in cancer

CY Yu, A Mitrofanova - Frontiers in Genetics, 2021 - frontiersin.org
Biomarker discovery is at the heart of personalized treatment planning and cancer precision
therapeutics, encompassing disease classification and prognosis, prediction of treatment …

Identification and validation of a novel DNA damage and DNA repair related genes based signature for colon cancer prognosis

X Wang, S Xu, W Wang, S Piao, X Mao, X Zhou… - Frontiers in …, 2021 - frontiersin.org
Backgrounds: Colorectal cancer (CRC) with high incidence, has the third highest mortality of
tumors. DNA damage and repair influence a variety of tumors. However, the role of these …

Translational Bioinformatics Applied to the study of Complex diseases

MC Casotti, DD Meira, LNR Alves, BGO Bessa… - Genes, 2023 - mdpi.com
Translational Bioinformatics (TBI) is defined as the union of translational medicine and
bioinformatics. It emerges as a major advance in science and technology by covering …

Combinatorial analyses reveal cellular composition changes have different impacts on transcriptomic changes of cell type specific genes in Alzheimer's Disease

TS Johnson, S Xiang, T Dong, Z Huang, M Cheng… - Scientific Reports, 2021 - nature.com
Alzheimer's disease (AD) brains are characterized by progressive neuron loss and gliosis.
Previous studies of gene expression using bulk tissue samples often fail to consider …

Prediction of Prognosis, Immunotherapy and Chemotherapy with an Immune-Related Risk Score Model for Endometrial Cancer

W Wei, B Ye, Z Huang, X Mu, J Qiao, P Zhao, Y Jiang… - Cancers, 2023 - mdpi.com
Simple Summary Endometrial cancer (EC) is one of the most common gynecologic cancers.
However, its clinical therapy remains unsatisfying due to the lack of effective treatment …

[HTML][HTML] Acidic leucine-rich nuclear phosphoprotein-32A expression contributes to adverse outcome in acute myeloid leukemia

S Huang, Z Huang, C Ma, L Luo, YF Li… - Annals of …, 2020 - ncbi.nlm.nih.gov
Background Acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) is a novel regulator
of histone H3 acetylation and promotes leukemogenesis in acute myeloid leukemia (AML) …

Co-PATHOgenex web application for assessing complex stress responses in pathogenic bacteria

L Fernandez, M Rosvall, J Normark… - Microbiology …, 2024 - Am Soc Microbiol
Pathogenic bacteria encounter various stressors while residing in the host. They respond
through intricate mechanisms of gene expression regulation, ensuring their survival and …

ALRIGMR: Adaptive logistic regression via integrating gene mutation and RNA-seq for liver cancer diagnosis

J Li, F Cao, H Zhang - Biomedical Signal Processing and Control, 2024 - Elsevier
RNA-seq is often used for early accurate diagnosis and related gene screening of liver
cancer, significantly improving patients' survival rates. Popular diagnostic methods based on …

Aberrant Chloride Intracellular Channel 4 Expression Is Associated With Adverse Outcome in Cytogenetically Normal Acute Myeloid Leukemia

S Huang, Z Huang, P Chen, C Feng - Frontiers in oncology, 2020 - frontiersin.org
Background and Methods: Acute myeloid leukemia (AML), which starts in the bone marrow,
is a group of hematopoietic stem cell disorders. Chloride intracellular channel 4 (CLIC4) is …