Retinal ganglion cell (RGC) death in glaucoma and other optic neuropathies results in
irreversible vision loss due to the mammalian central nervous system's limited regenerative …

Ocular diseases associated with retinal ganglion cell (RGC) degeneration is the most
common neurodegenerative disorder that causes irreversible blindness worldwide. It is …

The development of the visual system involves the coordination of spatial and temporal
events to specify the organization of varied cell types, including the elongation of axons from …

Human pluripotent stem cell (hPSC)-derived retinal organoids (ROs) can efficiently and
reproducibly generate retinal neurons that have potential for use in cell replacement …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the
accumulation of Aβ plaques and neurofibrillary tangles, resulting in synaptic loss and …

Retinal ganglion cells (RGCs) serve as the connection between the eye and the brain, with
this connection disrupted in glaucoma. Numerous cellular mechanisms have been …

Although the degeneration of retinal ganglion cells (RGCs) is a primary characteristic of
glaucoma, astrocytes also contribute to their neurodegeneration in disease states. Although …

Astrocytes influence neuronal maturation and function by providing trophic support,
regulating the extracellular environment, and modulating signaling at synapses. The …

Astrocytes, the main supportive cell type of the brain, show functional impairments upon
ageing and in a broad spectrum of neurological disorders. Limited access to human …

Glaucoma, one of the most common causes of blindness in developing countries today,
involves a progressive loss of neural cells in the optic nerve that leads to progressive …