With the global prevalence of type 2 diabetes mellitus steeply rising, instances of chronic,
hard-healing, or non-healing diabetic wounds and ulcers are predicted to increase. The …

Cell transplantation holds immense potential for reversing diseases that are currently
incurable and for regenerating tissues. However, poor cell survival, cell aggregation and …

The vascular network delivers oxygen (O2) and nutrients to all cells within the body. It is
therefore not surprising that O2 availability serves as a primary regulator of this complex …

Diverse subsets of endothelial progenitor cells (EPCs) are used for the treatment of ischemic
diseases in clinical trials, and circulating EPCs levels are considered as biomarkers for …

With the discovery of endothelial progenitor cells (EPCs) in the late 1990s, a paradigm shift
in the concept of neoangiogenesis occurred. The identification of circulating EPCs in …

Type 2 diabetes is characterized by a two-to fourfold increased risk of cardiovascular
disease. This is generally attributed to the adverse effects of hyperglycemia and oxidative …

The vascular system delivers oxygen and nutrients to every cell in the vertebrate organism.
Hypoxia-inducible factor 1 (HIF-1) is a master regulator of hypoxic/ischaemic vascular …

The prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide, especially as a
result of our aging society, high caloric intake and sedentary lifestyle. Besides the well …

Nitric oxide (NO) has been suggested to be a pathophysiological modulator of cell
proliferation, cell cycle arrest, and apoptosis. In this context, NO can exert opposite effects …

Endothelial progenitor cells (EPCs) are essential in vasculogenesis and wound healing, but
their circulating and wound level numbers are decreased in diabetes. This study aimed to …