In order to directly functionalize C− H bonds of complex molecules and, in particular, to
control the regioselectivity of the reaction, a wide range of directing groups has been used …

Transition metal‐catalyzed site‐and stereoselective C− H activation of strained (hetero)
cycloalkanes remains a formidable challenge. We herein report a carbamate‐directed …

Pd (II)-catalyzed γ-C (sp3)–H (hetero) arylation of aliphatic ketones is developed using α-
amino acids as transient directing groups (TDG). A variety of aliphatic ketones were (hetero) …

Chiral secondary alkyl amines with a vicinal quaternary stereocenter are undoubtedly
important and ubiquitous subunits in natural products and pharmaceuticals. However, their …

3d-Metal-catalyzed tertiary C (sp3)–H bond activation has been a formidable challenge.
Herein, a tertiary C (sp3)–H bond is smoothly activated by Ni–Al bimetallic catalysts for dual …

A palladium (0)-catalyzed β-C (sp3)–H arylation of silyl prop-1-en-1-ol ethers with aryl
halides for the synthesis of α, β-unsaturated ketones is presented. In contrast to the reported …

Selective CH bond functionalization of organic molecules has developed as an increasingly
versatile platform that found wide applications in the synthesis of naturally occurring …

We present the first example of nickel (II)-catalyzed β-C (sp3)–H thiolation of ketones,
employing 2-hydrazinopyridine as an efficient directing group. This approach enables the …

With alanine as a transient directing group, Pd-catalyzed regioselective alkynylation at the
indole C4-position was successfully established in a good yield. The total synthesis of the …

Abstract 'Transient'C− H functionalization has emerged in recent years to describe the use of
a dynamic linkage, often an imine, to direct cyclometallation and subsequent …