Cryogenic electron microscopy (cryo-EM) enables structure determination of
macromolecular objects and their assemblies. Although the techniques have been …

This review deals with the roles of calcium ions and ATP in the control of the normal
functions of the different cell types in the exocrine pancreas as well as the roles of these …

The serum level of iron in humans is tightly controlled by the action of the hormone hepcidin
on the iron efflux transporter ferroportin. Hepcidin regulates iron absorption and recycling by …

Many transient receptor potential (TRP) channels respond to diverse stimuli and
conditionally conduct small and large cations. Such functional plasticity is presumably …

The initial step in the sensory transduction pathway underpinning hearing and balance in
mammals involves the conversion of force into the gating of a mechanosensory transduction …

Our sense of smell enables us to navigate a vast space of chemically diverse odour
molecules. This task is accomplished by the combinatorial activation of approximately 400 …

Mechanosensitive (MS) ion channels are a ubiquitous type of molecular force sensor
sensing forces from the surrounding bilayer. The profound structural diversity in these …

Abstract SARS-CoV-2 ORF3a is a putative viral ion channel implicated in autophagy
inhibition, inflammasome activation and apoptosis. 3a protein and anti-3a antibodies are …

OSCA/TMEM63s form mechanically activated (MA) ion channels in plants and animals,
respectively. OSCAs and related TMEM16s and transmembrane channel-like (TMC) …

The proteins that form the permeation pathway of mechanosensory transduction channels in
inner-ear hair cells have not been definitively identified. Genetic, anatomical, and …