Glioma epigenetics: from subclassification to novel treatment options
O Gusyatiner, ME Hegi - Seminars in cancer biology, 2018 - Elsevier
Gliomas are the most common malignant primary brain tumors, of which glioblastoma is the
most malignant form (WHO grade IV), and notorious for treatment resistance. Over the last …
most malignant form (WHO grade IV), and notorious for treatment resistance. Over the last …
[HTML][HTML] Glioblastoma targeted therapy: updated approaches from recent biological insights
Glioblastoma (WHO grade IV astrocytoma) is the most frequent primary brain tumor in adults,
representing a highly heterogeneous group of neoplasms that are among the most …
representing a highly heterogeneous group of neoplasms that are among the most …
EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation
The emergence of resistance to poly-ADP-ribose polymerase inhibitors (PARPi) poses a
threat to the treatment of BRCA1 and BRCA2 (BRCA1/2)-deficient tumours. Stabilization of …
threat to the treatment of BRCA1 and BRCA2 (BRCA1/2)-deficient tumours. Stabilization of …
SIRT6 suppresses pancreatic cancer through control of Lin28b
S Kugel, C Sebastián, J Fitamant, KN Ross, SK Saha… - Cell, 2016 - cell.com
Chromatin remodeling proteins are frequently dysregulated in human cancer, yet little is
known about how they control tumorigenesis. Here, we uncover an epigenetic program …
known about how they control tumorigenesis. Here, we uncover an epigenetic program …
Widespread 8-oxoguanine modifications of miRNA seeds differentially regulate redox-dependent cancer development
Oxidative stress contributes to tumourigenesis by altering gene expression. One
accompanying modification, 8-oxoguanine (o8G) can change RNA–RNA interactions via …
accompanying modification, 8-oxoguanine (o8G) can change RNA–RNA interactions via …
The roles of EZH2 in cancer and its inhibitors
Y Liu, Q Yang - Medical Oncology, 2023 - Springer
The enhancer of zeste homolog 2 (EZH2) is encoded by the Enhancer of zeste 2 polycomb
repressive complex 2 subunit gene. EZH2 is involved in the cell cycle, DNA damage repair …
repressive complex 2 subunit gene. EZH2 is involved in the cell cycle, DNA damage repair …
Malignant glioma
LM Wang, ZK Englander, ML Miller… - Human Brain and Spinal …, 2023 - Springer
This chapter provides a comprehensive overview of malignant gliomas, the most common
primary brain tumor in adults. These tumors are varied in their cellular origin, genetic profile …
primary brain tumor in adults. These tumors are varied in their cellular origin, genetic profile …
[HTML][HTML] DNA repair mechanisms and their clinical impact in glioblastoma
H Erasimus, M Gobin, S Niclou, E Van Dyck - Mutation Research/Reviews …, 2016 - Elsevier
Despite surgical resection and genotoxic treatment with ionizing radiation and the DNA
alkylating agent temozolomide, glioblastoma remains one of the most lethal cancers, due in …
alkylating agent temozolomide, glioblastoma remains one of the most lethal cancers, due in …
MicroRNA in glioblastoma: an overview
B Banelli, A Forlani, G Allemanni… - … journal of genomics, 2017 - Wiley Online Library
Glioblastoma is the most aggressive brain tumor and, even with the current multimodal
therapy, is an invariably lethal cancer with a life expectancy that depends on the tumor …
therapy, is an invariably lethal cancer with a life expectancy that depends on the tumor …
G-tract RNA removes Polycomb repressive complex 2 from genes
Abstract Polycomb repressive complex 2 (PRC2) maintains repression of cell-type-specific
genes but also associates with genes ectopically in cancer. While it is currently unknown …
genes but also associates with genes ectopically in cancer. While it is currently unknown …