More than 80 years ago, the first Polycomb-related phenotype was identified in Drosophila
melanogaster. Later, a group of diverse genes collectively called Polycomb group (PcG) …

Human development requires intricate cell specification and communication pathways that
allow an embryo to generate and appropriately connect more than 200 different cell types …

Polycomb group (PcG) proteins are crucial chromatin regulators that maintain repression of
lineage-inappropriate genes and are therefore required for stable cell fate. Recent advances …

BACKGROUND Multicellular organisms depend on the precise orchestration of gene
expression to direct embryonic development and to maintain tissue homeostasis through …

Chromatin modifying activities inherent to polycomb repressive complexes PRC1 and PRC2
play an essential role in gene regulation, cellular differentiation, and development. However …

The chromatin environment is essential for the correct specification and preservation of cell
identity through modulation and maintenance of transcription patterns. Many chromatin …

Polycomb group (PcG) proteins are epigenetic gene silencers that are implicated in
neoplastic development. Their oncogenic function might be associated with their well …

Abstract In many higher organisms, 5%–15% of histone H2A is ubiquitylated at lysine 119
(uH2A). The function of this modification and the factors involved in its establishment …

Polycomb group (PcG) proteins exist in at least two biochemically distinct protein complexes,
the EED-EZH2 complex and the PRC1 complex, that respectively possess H3-K27 …

A crucial aspect of development, homeostasis and prevention of disease is the strict
maintenance of patterns of gene repression. Gene repression is largely achieved by the …