Cardiac development and function are becoming increasingly well understood from different
angles, including signalling, transcriptional and epigenetic mechanisms. By contrast, the …

We introduce Single-cell Nanopore Spatial Transcriptomics (scNaST), a software suite to
facilitate the analysis of spatial gene expression from second-and third-generation …

RNA splicing is an important RNA processing step required by multiexon protein-coding
mRNAs and some noncoding RNAs. Precise RNA splicing is required for maintaining gene …

Allele-specific expression (ASE) analysis detects the relative abundance of alleles at
heterozygous loci as a proxy for cis-regulatory variation, which affects the personal …

Background Atrial fibrillation (AF) can either be a consequence or an underlying mechanism
of left ventricular systolic dysfunction. Patients included in the CASTLE-AF (Catheter …

Smyd1, a member of the Smyd lysine methyltransferase family, plays an important role in
myofibrillogenesis of skeletal and cardiac muscles. Loss of Smyd1b (a Smyd1 ortholog) …

The giant protein titin is an essential component of muscle sarcomeres. A single titin
molecule spans half a sarcomere and mediates diverse functions along its length by virtue of …

Alternative splicing is a complex gene regulatory process that distinguishes itself from
canonical splicing by rearranging the introns and exons of an immature pre-mRNA …

Heart failure (HF) represents the advanced stage of several cardiovascular disorders. This
study aimed to build an alternative splicing regulatory network and identify potential splicing …

Heart failure (HF) is highly prevalent. Mechanisms underlying HF remain incompletely
understood. Splicing factors (SF), which control pre‐mRNA alternative splicing, regulate …