Background Current guidelines stress the importance of exercise, especially
multicomponent exercise to older adults with chronic conditions. Aim To critically synthesise …

The UK Biobank (UKB) has the largest adult brain imaging dataset, which encompasses
over 40,000 participants. A significant number of Mendelian randomization (MR) studies …

Background Although existing studies have indicated a connection between chronic low-
grade inflammation and the onset of frozen shoulder (FS), the precise causal relationship …

Objective Promoting preventive healthcare service utilization is essential for disease
prevention. This study explored the association between depressive symptoms and …

Background Previous studies have shown that migraines are associated with brain structural
changes. However, the causal relationships between these changes and migraine, as well …

Background Evidence links major depressive disorder (MDD) with aging, but it's unclear if
MDD accelerates aging and what factors mediate this transition. Methods Two-sample …

Background Previous studies have revealed structural brain abnormalities in individuals
with depression, but the causal relationship between depression and brain structure …

Background The bidirectional relationship between cognitive function and depressive
symptoms has been extensively reported. However, the potential mechanisms are still not …

Background: The study aimed to examine the bidirectional relationship between sarcopenia
and depressive symptoms in a national, community-based cohort study, despite the unclear …

Major depressive disorder (MDD) and obesity have a complex bidirectional relationship.
However, most studies do not assess increased appetite or weight as a depressive symptom …