Interleukin-10 in cancer immunotherapy: from bench to bedside
MA Salkeni, A Naing - Trends in Cancer, 2023 - cell.com
Abstract Interleukin (IL)-10 was one of the first cytokines to be recognized. However, its
functionality in promoting antitumor immunity was described more recently. Context-and …
functionality in promoting antitumor immunity was described more recently. Context-and …
Cervical cancer and HPV infection: ongoing therapeutic research to counteract the action of E6 and E7 oncoproteins
AM Almeida, JA Queiroz, F Sousa, Â Sousa - Drug discovery today, 2019 - Elsevier
Highlights•Human papillomavirus (HPV) has a primordial role in the development of cervical
cancer.•Therapies currently available for cervical cancer treatment are reviewed.•The …
cancer.•Therapies currently available for cervical cancer treatment are reviewed.•The …
Single immunizations of self-amplifying or non-replicating mRNA-LNP vaccines control HPV-associated tumors in mice
J Ramos da Silva, K Bitencourt Rodrigues… - Science Translational …, 2023 - science.org
As mRNA vaccines have proved to be very successful in battling the coronavirus disease
2019 (COVID-19) pandemic, this new modality has attracted widespread interest for the …
2019 (COVID-19) pandemic, this new modality has attracted widespread interest for the …
IL‐10‐induced STAT3/NF‐κB crosstalk modulates pineal and extra‐pineal melatonin synthesis
MO Córdoba‐Moreno, GC Santos… - Journal of Pineal …, 2024 - Wiley Online Library
Immune‐pineal axis activation is part of the assembly of immune responses.
Proinflammatory cytokines inhibit the pineal synthesis of melatonin while inducing it in …
Proinflammatory cytokines inhibit the pineal synthesis of melatonin while inducing it in …
Targeting interleukin-10 signalling for cancer immunotherapy, a promising and complicated task
G Ni, L Zhang, X Yang, H Li, B Ma… - Human vaccines & …, 2020 - Taylor & Francis
ABSTRACT Interleukin 10 (IL-10) belongs to IL-10 family cytokines that are critical for
maintaining the integrity of epithelial tissues, protecting pathogenic infection, and preventing …
maintaining the integrity of epithelial tissues, protecting pathogenic infection, and preventing …
[HTML][HTML] Antigen delivery to DEC205+ dendritic cells induces immunological memory and protective therapeutic effects against HPV-associated tumors at different …
The generation of successful anticancer vaccines relies on the ability to induce efficient and
long-lasting immune responses to tumor antigens. In this scenario, dendritic cells (DCs) are …
long-lasting immune responses to tumor antigens. In this scenario, dendritic cells (DCs) are …
Interleukin-6 and indoleamine-2, 3-dioxygenase as potential adjuvant targets for Papillomavirus-related tumors immunotherapy
RL Pagni, PC Souza, R Pegoraro… - Frontiers in …, 2022 - frontiersin.org
High-risk Human papillomavirus (HPV) infections represent an important public health issue.
Nearly all cervical malignancies are associated with HPV, and a range of other female and …
Nearly all cervical malignancies are associated with HPV, and a range of other female and …
PLGA-Chitosan Encapsulated IL-10 Nanoparticles Modulate Chlamydia Inflammation in Mice
AN Yilma, R Sahu, P Subbarayan… - International Journal …, 2024 - Taylor & Francis
Introduction Interleukin-10 (IL-10) is a key anti-inflammatory mediator in protecting host from
over-exuberant responses to pathogens and play important roles in wound healing …
over-exuberant responses to pathogens and play important roles in wound healing …
Nanoengineered drug delivery in cancer immunotherapy for overcoming immunosuppressive tumor microenvironment
SH Park, R Eun, J Heo, YT Lim - Drug Delivery and Translational …, 2023 - Springer
Almost like a living being in and of itself, tumors actively interact with and modify their
environment to escape immune responses. Owing to the pre-formation of cancer-favorable …
environment to escape immune responses. Owing to the pre-formation of cancer-favorable …
Inhibition of MC38 colon cancer growth by multicomponent chemoimmunotherapy with anti-IL-10R antibodies, HES-MTX nanoconjugate, depends on application of IL …
K Węgierek-Ciura, J Mierzejewska… - Frontiers in …, 2023 - frontiersin.org
Background The tumor microenvironment (TME) provides a conducive environment for the
growth and survival of tumors. Negative factors present in TME, such as IL-10, may limit the …
growth and survival of tumors. Negative factors present in TME, such as IL-10, may limit the …