DNA damage repair mechanisms are vital to maintain genomic integrity. Mutations in genes
involved in the DNA damage response (DDR) can increase the risk of developing cancer. In …

DNA repair pathways, which are also identified as guardians of the genome, protect cells
from frequent damage that can lead to DNA breaks. The most deleterious types of damage …

Background: Evidence is increasingly emerging about multiple roles for the NAD (P) H
quinone oxidoreductase 1 enzyme in cancer. The C609T (rs1800566, Pro187Ser) null …

Therapy-related myeloid neoplasms (t-MN) include acute myeloid leukemias and
myelodysplastic syndromes arising in patients who have been treated with chemotherapy …

Purpose: Epigenetic changes play a role and cooperate with genetic alterations in the
pathogenesis of myelodysplastic syndromes (MDS). We conducted a phase II multicenter …

Abstract CYP450 3A4 (CYP3A4), encoded by the CYP3A4 gene, is a major enzyme
catalyzing the metabolism of both endogenous and exogenous agents that may play a role …

Forkhead box (FOX) proteins are a group of transcriptional factors implicated in different
cellular functions such as differentiation, proliferation and senescence. A growing number of …

Oxidative stress is associated with several acute and chronic disorders, including
hematological malignancies such as acute myeloid leukemia, the most prevalent acute …

The genetic polymorphisms of X‐ray repair cross complementing group 1 (XRCC1), X‐ray
repair cross complementing group 3 (XRCC3), and xeroderma pigmentosum …

In acute myeloid leukemia (AML), cytogenetics predicts treatment outcome for the favorable
and poor subgroups but not for the intermediate subgroup. Polymorphisms within the …