Background The insulin/IGF-1 signaling pathway has a major role in the regulation of
longevity both in Caenorhabditis elegans and mammalian species, ie, reduced activity of …

Signal transducer and activator of transcription (STAT) proteins are a 7-member family of
cytoplasmic transcription factors that contribute to signal transduction by cytokines …

Acetylcholine released by efferent vagus nerves inhibits macrophage activation. Here we
show that the anti-inflammatory action of nicotinic receptor activation in peritoneal …

Signal transducers and activators of transcription (STATs) are cytoplasmic transcription
factors that have a key role in cell fate. STATs, a protein family comprised of seven members …

Stat3 is constitutively activated in many human cancers where it functions as a critical
mediator of oncogenic signaling through transcriptional activation of genes encoding …

Granulocytes and monocytes develop from a common myeloid progenitor. Early
granulopoiesis requires the C/EBPα, PU. 1, RAR, CBF, and c-Myb transcription factors, and …

The signal transducer and activator of transcription (STAT) proteins relay signals from
cytokine receptors and receptor tyrosine kinases on the cell surface to the nucleus, where …

A major function of p27, also known as Kip1, is to bind and inhibit cyclin/cyclin-dependent
kinase complexes, thereby blocking cell cycle progression. As p27 operates at the heart of …

Signal transducer and activator of transcription 3 (STAT3) has oncogenic potential. The
biological effects of STAT3 have not been studied extensively in the pathogenesis of colon …

The impaired regenerative capacity of fatty livers might promote the progression of
nonalcoholic fatty liver disease (NAFLD). To identify mechanisms involved, regenerative …