Nutrient composition and caloric intake have traditionally been used to devise optimized
diets for various phases of life. Adjustment of meal size and frequency have emerged as …

Reduced food intake, avoiding malnutrition, can ameliorate aging and aging-associated
diseases in invertebrate model organisms, rodents, primates, and humans. Recent findings …

Cancer is a disease characterized by unrestrained cellular proliferation. In order to sustain
growth, cancer cells undergo a complex metabolic rearrangement characterized by changes …

Chronic calorie restriction (CR) improves cardiovascular function and several other
physiological markers of healthspan. However, CR is impractical in non-obese older …

As the aging population in developed countries is growing in both numbers and percentage,
the medical, social, and economic burdens posed by nonhealing wounds are increasing …

Dietary restriction (DR) under laboratory conditions generally extends life span and delays
ageing across species as diverse as yeast, nematode worms, flies and mice, and is …

Resveratrol is a well-known polyphenol that harbors various health benefits. Besides its well-
known anti-oxidative potential, resveratrol exerts anti-inflammatory, pro-angiogenic, and cell …

Dietary restriction (DR) has long been viewed as the most robust nongenetic means to
extend lifespan and healthspan. Many aging-associated mechanisms are nutrient …

Cellular senescence is a state of irreversible growth arrest characterized by hypertrophy and
secretion of various bioactive molecules, a phenomenon defined the Senescence …

The calorie restriction paradigm has provided one of the most widely used and most useful
tools for investigating mechanisms of aging and longevity. By far, rodent models have been …