Topical delivery to the various regions of the skin and underlying tissues, transdermal drug
delivery and dermal exposure to environmental chemicals are important areas of research …

Due to the increased demand for reliable data regarding penetration into and permeation
across human skin, assessment of the absorption of xenobiotics has been gaining in …

Protein–water partition coefficients (K pw) of neutral organic chemicals were measured
using muscle proteins (from chicken, fish, and pig), collagen and gelatin. K pw values for …

The human nail plate is a formidable barrier to drug permeation. Development of
therapeutics for management of nail diseases thus remains a challenge. This article reviews …

Understanding the permeation of hydrophilic molecules is of relevance to many applications
including transdermal drug delivery, skin care as well as risk assessment of occupational …

Onychomycosis is difficult to treat topically due to the deep location of the infection under the
densely keratinized nail plate. In order to obtain an in vitro index that is relevant to the …

The in vivo partitioning behavior of ionogenic organic chemicals (IOCs) is of paramount
importance for their toxicokinetics and bioaccumulation. Among other proteins, structural …

To use a diffusion model for predicting skin absorption requires accurate estimates of input
parameters on model geometry, affinity and transport characteristics. This review …

To measure progress and evaluate performance of the newest UB/UC/P&G skin penetration
model we simulated an 18-compound subset of finite dose in vitro human skin permeation …

Introduction: The use of epicutaneously applied permethrin in the treatment of common
scabies is considered to be the first-line therapy. Due to increasing clinical treatment failure …